国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2013年
5期
359-362
,共4页
内毒素血症%肝脏疾病
內毒素血癥%肝髒疾病
내독소혈증%간장질병
Endotoxemia%Liver diseases
内毒素是革兰阴性细菌细胞壁中的脂多糖(LPS)组分.只有当细菌死亡溶解或用人工方法破坏菌细胞后才释放出来.血中细菌或病灶内细菌释放出大量内毒素至血液,或输入大量内毒素污染的液体而引起的一种病理生理表现称作内毒素血症.内毒素血症可以导致多种肝脏疾病的产生,其发生机制比较复杂,其中Toll样受体-4(TLR4)、CD14受体及Kupffer细胞在内毒素性肝损害的发生发展中起着重要作用.近年来,对于内毒素血症和肝脏疾病的临床和实验研究有了较大进展.
內毒素是革蘭陰性細菌細胞壁中的脂多糖(LPS)組分.隻有噹細菌死亡溶解或用人工方法破壞菌細胞後纔釋放齣來.血中細菌或病竈內細菌釋放齣大量內毒素至血液,或輸入大量內毒素汙染的液體而引起的一種病理生理錶現稱作內毒素血癥.內毒素血癥可以導緻多種肝髒疾病的產生,其髮生機製比較複雜,其中Toll樣受體-4(TLR4)、CD14受體及Kupffer細胞在內毒素性肝損害的髮生髮展中起著重要作用.近年來,對于內毒素血癥和肝髒疾病的臨床和實驗研究有瞭較大進展.
내독소시혁란음성세균세포벽중적지다당(LPS)조분.지유당세균사망용해혹용인공방법파배균세포후재석방출래.혈중세균혹병조내세균석방출대량내독소지혈액,혹수입대량내독소오염적액체이인기적일충병리생리표현칭작내독소혈증.내독소혈증가이도치다충간장질병적산생,기발생궤제비교복잡,기중Toll양수체-4(TLR4)、CD14수체급Kupffer세포재내독소성간손해적발생발전중기착중요작용.근년래,대우내독소혈증화간장질병적림상화실험연구유료교대진전.
Endotoxin is the lipopolysaccharide (LPS)component of the Gram-negative bacterial cell wall.It can be released when the bacteria are dissolved after death or damaged by artificialmeans.Endotoxemia is known as a pathophysiological manifestation that is caused by the release a large amounts of endotoxin form the bacterial to blood.Transfusion of a large amount of liquid polluted by endotoxin can also cause endotoxemia.Endotoxemia can lead to a variety of liver diseases with unknownmechanism,Toll-like receptor-4 (TLR4),CD14 receptor and Kupffer cells play important roles in the development of endotoxin-induced liver injury.
