CAJ | 학술논문

固有免疫是生物体长期种系进化过程中形成的一系列防御机制.其可对侵入的病原体迅速产生应答,发挥非特异抗感染免疫作用.在固有免疫中,白细胞的募集和激活是很有必要的,可被各种化学介质调控,这其中就包括细胞因子.研究表明,信号转导和转录激活因子(STAT)蛋白在脓毒症期间大鼠的固有免疫中起着重要作用,并且不同的细胞因子活化的STAT不同.STAT1、STAT3、STAT4和STAT6可以分别介导IFN-γ、IL-10、IL-12和IL-13信号.细胞因子信号转导抑制因子(SOCS)是对细胞因子应答而迅速被诱导的蛋白质家族,可以通过JAK/STAT信号途径减弱细胞因子的信号传导,由此将为治疗脓毒血症提供了理论依据.
고유면역시생물체장기충계진화과정중형성적일계렬방어궤제.기가대침입적병원체신속산생응답,발휘비특이항감염면역작용.재고유면역중,백세포적모집화격활시흔유필요적,가피각충화학개질조공,저기중취포괄세포인자.연구표명,신호전도화전록격활인자(STAT)단백재농독증기간대서적고유면역중기착중요작용,병차불동적세포인자활화적STAT불동.STAT1、STAT3、STAT4화STAT6가이분별개도IFN-γ、IL-10、IL-12화IL-13신호.세포인자신호전도억제인자(SOCS)시대세포인자응답이신속피유도적단백질가족,가이통과JAK/STAT신호도경감약세포인자적신호전도,유차장위치료농독혈증제공료이론의거.
The innate immunity is a series of defense mechanisms,formed in evolution.It provides immediate defense against infection and plays a role of non-specific anti-infection responses,In innate immunity,the recruitment and activation of leukocytes are necessary and are governed by a variety of chemical mediators including cytokines.Recent study shows STATs play an important role in the innate immunity during sepsis.Different cytokines can be activated through different STATs,STAT1,STAT3,STAT4 and STAT6 can mediate IFN-γ,IL-1O,IL-12 and IL-13 Suppressor of cytokine signaling (SOCS)are negative regulators of cytokine signalingby inhibiting JAK/STAT signal pathway.