CAJ | 학술논문

IL-7是一种具有多种生物学功能的细胞因子,通过影响T、B淋巴细胞的成熟、分化及其他细胞因子的分泌,在炎症的发生发展过程中起到了重要作用.干燥综合征(SS)是一种以外分泌腺体高度淋巴细胞浸润和淋巴瘤高发生率为特征的炎症性自身免疫性疾病.IL-7/IL-7R的高表达与SS的发病机制及病情进展关系密切,因此通过封锁IL-7/IL-7R可能会阻止SS患者炎症和组织破坏的发生,可能会为临床治疗SS提供一种新的途径.
IL-7시일충구유다충생물학공능적세포인자,통과영향T、B림파세포적성숙、분화급기타세포인자적분비,재염증적발생발전과정중기도료중요작용.간조종합정(SS)시일충이외분비선체고도림파세포침윤화림파류고발생솔위특정적염증성자신면역성질병.IL-7/IL-7R적고표체여SS적발병궤제급병정진전관계밀절,인차통과봉쇄IL-7/IL-7R가능회조지SS환자염증화조직파배적발생,가능회위림상치료SS제공일충신적도경.
Interleukin-7 (IL-7)is a kind of cytokine with a variety of biological functions.It plays an important role in the process of inflammation development by influencing the maturation,differentiation of T and B lymphocytes,and the secretion of cytokines.Sjogren's syndrome (SS)is an inflammatory autoimmune diseasecharacterized by lymphocyte infiltration in secretory glands and high incidence of lymphoma.The high expression of IL-7 / IL-7R is related to the pathogenesis and progression of SS.Therefore,blocking IL-7/IL-7R might prevent inflammation and tissue destruction in SS and provide a new approach for the treatment of SS.