国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2014年
1期
1-5
,共5页
慢性乙型肝炎%免疫治疗%治疗性疫苗%联合疗法
慢性乙型肝炎%免疫治療%治療性疫苗%聯閤療法
만성을형간염%면역치료%치료성역묘%연합요법
Chronic hepatitis B%Immune based therapy%Therapeutic vaccine%Combination therapy
乙型肝炎预防性疫苗成功地降低了HBV的感染率,但是HBV感染仍然是全球性的健康问题.目前针对HBV感染导致的慢性乙型肝炎尚无完全有效的治疗方法.慢性乙型肝炎的免疫治疗是近年来的研究热点,尤其治疗性疫苗更是一种很有前景的治疗策略.慢性乙型肝炎治疗性疫苗目的在于诱导HBV特异性的免疫应答,打破免疫耐受,最终清除HBV.随着对HBV感染后临床转归机制研究的进一步透彻,慢性乙型肝炎免疫治疗的研究也取得显著进展.
乙型肝炎預防性疫苗成功地降低瞭HBV的感染率,但是HBV感染仍然是全毬性的健康問題.目前針對HBV感染導緻的慢性乙型肝炎尚無完全有效的治療方法.慢性乙型肝炎的免疫治療是近年來的研究熱點,尤其治療性疫苗更是一種很有前景的治療策略.慢性乙型肝炎治療性疫苗目的在于誘導HBV特異性的免疫應答,打破免疫耐受,最終清除HBV.隨著對HBV感染後臨床轉歸機製研究的進一步透徹,慢性乙型肝炎免疫治療的研究也取得顯著進展.
을형간염예방성역묘성공지강저료HBV적감염솔,단시HBV감염잉연시전구성적건강문제.목전침대HBV감염도치적만성을형간염상무완전유효적치료방법.만성을형간염적면역치료시근년래적연구열점,우기치료성역묘경시일충흔유전경적치료책략.만성을형간염치료성역묘목적재우유도HBV특이성적면역응답,타파면역내수,최종청제HBV.수착대HBV감염후림상전귀궤제연구적진일보투철,만성을형간염면역치료적연구야취득현저진전.
Although prophylactic HBV vaccine has reduced the incidence,hepatitis B is still a worldwide health problem.Till now,there is no perfect treatment for chronic hepatitis B caused by HBV infection.Nowadays,Immune based therapies of chronic hepatitis B,especially therapeutic vaccine,become a research hotspot as promising new strategy.Therapeutic vaccine aims to induce HBV specific immune response,to break immune tolerance and eventually to clear the HBV.Immune based therapy research has made significant progress.Moreover,new insight has been abtained by the researches on the mechanism of the clinical outcomes after HBV infection.
