CAJ | 학술논문

免疫系统通过固有和适应性免疫监督来防止肿瘤的发生、进展,但是仍然有肿瘤细胞逃脱免疫网络的监视,在体内大量繁殖,调节性T细胞(Treg)就是帮助肿瘤细胞逃脱的原因之一,所以靶向Treg的治疗是肿瘤免疫治疗的关键.了解Treg上的各种功能分子及其作用,Treg的来源以及转化方式,对阐明其调控靶点,进而概述靶向Treg的治疗方式很有意义.
면역계통통과고유화괄응성면역감독래방지종류적발생、진전,단시잉연유종류세포도탈면역망락적감시,재체내대량번식,조절성T세포(Treg)취시방조종류세포도탈적원인지일,소이파향Treg적치료시종류면역치료적관건.료해Treg상적각충공능분자급기작용,Treg적래원이급전화방식,대천명기조공파점,진이개술파향Treg적치료방식흔유의의.
The immune system prevents organism from the occurrence and progress of tumor drawing assistance from innate and adaptive immune surveillance.However,some tumor cells could escape from the monitoring of immune network,and bloom in the body.Regulatory T cells plays a vital role during this progression,therefore,the therapies targeting regulatory T cells is the key point of tumor immunotherapy.In order to find some therapeutic target spots,we analyzed the role of various functional molecules of the regulatory T cells,the origin of regulatory T cells and its transformation.In conclusion,we summarized several therapies targeting regulatory T cells which could inhibit the malignant progression of tumor.