CAJ | 학술논문

SELEX技术利用大容量的随机寡核苷酸文库与靶分子的相互作用,从中筛选出高亲和力和高特异性的寡核苷酸适配体.适配子和靶分子结合后可阻断靶分子的生物学活性,与相应抗体分子相比适配子具有许多优越性,如分子量小、易于修饰、无免疫原性等.该技术在多种疾病的诊断、治疗方面都有广泛的应用前景.
SELEX기술이용대용량적수궤과핵감산문고여파분자적상호작용,종중사선출고친화력화고특이성적과핵감산괄배체.괄배자화파분자결합후가조단파분자적생물학활성,여상응항체분자상비괄배자구유허다우월성,여분자량소、역우수식、무면역원성등.해기술재다충질병적진단、치료방면도유엄범적응용전경.
SELEX,a technique which utilizes the interaction of large capacity random oligonucleotide library with target molecules to screen and select aptamers with high affinity and high specificity.These aptamers are superior to antibodies in many aspects.They may substitute antibodies and inhibit the bioactivities of their targets.There is a broad potential of application for SELEX in the treatment of various diseases.