CAJ | 학술논문

由输血引发的急性肺损伤(TRALI)是输血相关的较为严重的非传染性并发症之一.大量的研究表明,TRALI是一种不可控的固有免疫系统介导的扩大化炎症反应,属于“自身炎症性疾病”.TRALI伴随的宿主炎症反应是在血液和血液成分收集和处理过程中由损害相关的分子模式(DAMPs)介导产生的,输血后这些DAMPs激活宿主的固有免疫系统,通过免疫系统的多种效应细胞和介质作用导致肺损伤.大量的研究致力于寻找血液及血液制品相关中潜在的DAMPs,以期对未来治疗方案设计和实施的进展提供有效的信息.
유수혈인발적급성폐손상(TRALI)시수혈상관적교위엄중적비전염성병발증지일.대량적연구표명,TRALI시일충불가공적고유면역계통개도적확대화염증반응,속우“자신염증성질병”.TRALI반수적숙주염증반응시재혈액화혈액성분수집화처리과정중유손해상관적분자모식(DAMPs)개도산생적,수혈후저사DAMPs격활숙주적고유면역계통,통과면역계통적다충효응세포화개질작용도치폐손상.대량적연구치력우심조혈액급혈액제품상관중잠재적DAMPs,이기대미래치료방안설계화실시적진전제공유효적신식.
Amongst the numerous possible complications,transfusion-related acute lung injury(TRALI) has emerged as the most important cause of morbidity and mortality resulting from transfusion of blood or blood components.TRALI may reflect an acute pulmonary disease caused by an exaggerated uncontrolled innate immune response.This concept has been supported by recent reports on an expanding spectrum of acute and chronic inflammatory diseases.TRALI-associated inflammatory response of the host is initiated by damage-associated molecular patterns (DAMPs) generated during collection,processing,and storage of blood/blood components.These DAMPs,after transfusion,are able to activate host innate immune system and to promote the formation of lung inflammation.To gain a more precise understanding of the potential role of innate immune events in TRALI,studies have to be devoted to search for potential DAMPs in blood/blood products in relation to processing methods and storage time.These studies may help investigators to design and to implement future treatment.