国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2014年
1期
30-34
,共5页
他汀类药物%免疫调节%B细胞
他汀類藥物%免疫調節%B細胞
타정류약물%면역조절%B세포
Statins%Immunoregulation%B cells
他汀类药物是临床常用的抗动脉粥样硬化药物,近年来其免疫调节作用倍受关注,研究发现,他汀类药物直接对B细胞增殖、凋亡、抗原提呈及其分化过程中的重要辅助成分ICOS-ICOSL、CD40-CD40L、BAFF、Tfh等产生调节作用,并可能通过调节Th1/Th2平衡间接调节B细胞功能.由于他汀类药物具有以上机制,因而其在系统性红斑狼疮、多发性硬化等疾病及B细胞耗竭治疗中发挥了作用.
他汀類藥物是臨床常用的抗動脈粥樣硬化藥物,近年來其免疫調節作用倍受關註,研究髮現,他汀類藥物直接對B細胞增殖、凋亡、抗原提呈及其分化過程中的重要輔助成分ICOS-ICOSL、CD40-CD40L、BAFF、Tfh等產生調節作用,併可能通過調節Th1/Th2平衡間接調節B細胞功能.由于他汀類藥物具有以上機製,因而其在繫統性紅斑狼瘡、多髮性硬化等疾病及B細胞耗竭治療中髮揮瞭作用.
타정류약물시림상상용적항동맥죽양경화약물,근년래기면역조절작용배수관주,연구발현,타정류약물직접대B세포증식、조망、항원제정급기분화과정중적중요보조성분ICOS-ICOSL、CD40-CD40L、BAFF、Tfh등산생조절작용,병가능통과조절Th1/Th2평형간접조절B세포공능.유우타정류약물구유이상궤제,인이기재계통성홍반랑창、다발성경화등질병급B세포모갈치료중발휘료작용.
Statins are commonly used in clinical practice as anti-atherosclerosis drugs.In recent years,its immunoregulatory role has attracted a lot of attention.Studies reported that statins can directly affect B cell' s proliferation,apoptosis,antigen presentation.Statins also affect ICOS-ICOSL,CD40-CD40L,BAFF,Tfh,the important auxilliary component in B cell differentiation and proliferation.In addition,statins adjust B cell activation indirectly through regulating Th1/Th2 cytokine balance.Through theses mechanisms,statins exert therapeutic effects in systemic lupus erythematosus,multiple sclerosis and B cell depletion therapy.
