CAJ | 학술논문

警报素(alarmins)是一类内源性介质,当机体受到危险信号刺激时,能被迅速释放到细胞外,趋化并激活抗原提呈细胞(APC)(尤其是树突状细胞),进而激发并促进固有免疫和适应性免疫.目前,关于警报素的研究主要集中在外伤后的全身炎症反应综合征(SIRS)、败血症的治疗以及免疫性疾病.因而了解警报素家族成员及其在创伤和疾病方面的最新研究进展很有意义.
경보소(alarmins)시일류내원성개질,당궤체수도위험신호자격시,능피신속석방도세포외,추화병격활항원제정세포(APC)(우기시수돌상세포),진이격발병촉진고유면역화괄응성면역.목전,관우경보소적연구주요집중재외상후적전신염증반응종합정(SIRS)、패혈증적치료이급면역성질병.인이료해경보소가족성원급기재창상화질병방면적최신연구진전흔유의의.
Alarmins,as endogenous mediators,could be rapidly released from cells in response to dangerous signals.Alarmin then recruits and activates antigen-presenting cells to enhance innate and adaptive immune responses.At present,the study of alarmins is predominantly concentrated on immune diseases,systemic inflammatory response syndrome (SIRS) and sepsis after trauma.Here,we introduce the members of alarmins and recent researches on alarmins in trauma and diseases.