CAJ | 학술논문

β防御素(BD)是人体固有免疫系统的重要成员之一,主要表达在皮肤、呼吸道、消化道和泌尿生殖道等上皮组织中.作为小分子阳离子抗菌肽,β防御素在体内外均表现出较强的抗菌和抗病毒性能,不易产生耐药性.近年来研究表明,β防御素作为炎症介质和趋化因子,参与固有免疫和适应性免疫应答反应,是机体防御屏障的重要组成部分.β防御素在较低浓度时,通过趋化中性粒细胞和巨噬细胞等减少炎症因子的表达,并表现出抗炎作用.在较高浓度时,通过趋化T细胞和未成熟DC细胞等分别引起初始免疫应答和记忆免疫应答的发生,而且β防御素趋化免疫细胞所需浓度远远低于表现出抗微生物所需的最低浓度.随着对其结构更深入的了解,将有助于探索β防御素在不同学科(如生殖、发育、组织修复和肿瘤)中的作用以及相关药物的研发.
β방어소(BD)시인체고유면역계통적중요성원지일,주요표체재피부、호흡도、소화도화비뇨생식도등상피조직중.작위소분자양리자항균태,β방어소재체내외균표현출교강적항균화항병독성능,불역산생내약성.근년래연구표명,β방어소작위염증개질화추화인자,삼여고유면역화괄응성면역응답반응,시궤체방어병장적중요조성부분.β방어소재교저농도시,통과추화중성립세포화거서세포등감소염증인자적표체,병표현출항염작용.재교고농도시,통과추화T세포화미성숙DC세포등분별인기초시면역응답화기억면역응답적발생,이차β방어소추화면역세포소수농도원원저우표현출항미생물소수적최저농도.수착대기결구경심입적료해,장유조우탐색β방어소재불동학과(여생식、발육、조직수복화종류)중적작용이급상관약물적연발.
Current evidence shows multiple and complementary roles of human beta defensins.It is clear that these structurally and functionally similar molecules are key parts of human immune system.In human,beta defensins are found mainly at epithelial surfaces,for example in the skin,lung and gut.In addition to antimicrobial ability,the function of beta defensins in immunomodulation,both as pro-inflammatory and anti-inflammatory mediators,has been widely studied.The induction of inflammatory cytokines was significantly suppressed by the presence of beta defensins at low concentration.However,at high concentration,beta defensins show pro-inflammatory effect.Structural investigations of beta defensins provide molecular basis for a better understanding of their properties in different processes (such as fertility,development,wound healing and cancer)and their potential as therapeutic agents.