CAJ | 학술논문

牙周炎是由牙周病原菌和宿主免疫防御系统长期相互作用所致的炎症性疾病,类风湿性关节炎(RA)是一类发病机制尚未完全阐明的自身免疫性疾病,二者在免疫病理学上有许多相似之处,特别是在促炎性介质分泌增加的情况下两种疾病均以慢性的骨组织破坏为主要临床特征.近年研究表明,牙周炎和类风湿性关节炎两者之间可能存在复杂的内在联系.IL-17是T淋巴细胞分泌的细胞因子,它在诱发、维持及促进炎症过程中发挥着重要作用,并且可以刺激破骨细胞导致骨吸收的发生.
아주염시유아주병원균화숙주면역방어계통장기상호작용소치적염증성질병,류풍습성관절염(RA)시일류발병궤제상미완전천명적자신면역성질병,이자재면역병이학상유허다상사지처,특별시재촉염성개질분비증가적정황하량충질병균이만성적골조직파배위주요림상특정.근년연구표명,아주염화류풍습성관절염량자지간가능존재복잡적내재련계.IL-17시T림파세포분비적세포인자,타재유발、유지급촉진염증과정중발휘착중요작용,병차가이자격파골세포도치골흡수적발생.
Periodontitis is an inflammatory disease caused by long term interaction between periodontal pathogens and host immune system.Rhumatoid arthritis is an autoimmune disease with pathogenesis not fully elucidated.These two diseases share many immunopathological features.In the case of increased secretion of proinflammatory mediators,both diseases are characterized by chronic bone tissue destruction.In recent years,studies have shown that a complicated interrelationship may exist between periodontitis and rheumatoid arthritis.Interleukin-17 (IL-17) is a T-cell-derived cytokine that may play an important role in the initiation and maintenance of the pro-inflammatory response,and can stimulate osteoclastic resorption.