国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2014年
2期
157-160
,共4页
磷脂酰肌醇蛋白多糖-1%趋化因子及受体7%胰腺癌%免疫组织化学
燐脂酰肌醇蛋白多糖-1%趨化因子及受體7%胰腺癌%免疫組織化學
린지선기순단백다당-1%추화인자급수체7%이선암%면역조직화학
Glypican-1%CXCR7%Pancreatic cancer%Immunohistochemistry
目的 探讨磷脂酰肌醇蛋白多糖-1(glypicans-1,GPC-1)与趋化因子受体CXCR7在胰腺癌中的表达及临床意义.方法 应用免疫组织化学方法检测52例胰腺癌组织及30例正常胰腺组织中GPC-1与CXCR7的表达及相关性,电话随访统计预后情况.结果 胰腺癌组织中GPC-1和CXCR7阳性表达率(56.79％、51.92％)均明显高于正常胰腺组织(x2=27.293、23.224,P均＜0.05),且二者的表达相互之间呈正相关性(r=0.758,P＜0.001),同时GPC-1和CXCR7的阳性表达与淋巴结是否转移相关(x2=14.470、14.034,P＜0.05).GPC-1与CXCR7的阳性表达与患者术后生存时间均无统计学意义(Log Rank =0.086、0.006,P均＜0.05).结论 GPC-1和CXCR7与胰腺癌的发生发展关系密切,且与其侵袭转移相关.二者的联合检测对胰腺癌的诊断具有一定意义,同时也可对胰腺癌的侵袭转移提供一项参考依据.
目的 探討燐脂酰肌醇蛋白多糖-1(glypicans-1,GPC-1)與趨化因子受體CXCR7在胰腺癌中的錶達及臨床意義.方法 應用免疫組織化學方法檢測52例胰腺癌組織及30例正常胰腺組織中GPC-1與CXCR7的錶達及相關性,電話隨訪統計預後情況.結果 胰腺癌組織中GPC-1和CXCR7暘性錶達率(56.79％、51.92％)均明顯高于正常胰腺組織(x2=27.293、23.224,P均＜0.05),且二者的錶達相互之間呈正相關性(r=0.758,P＜0.001),同時GPC-1和CXCR7的暘性錶達與淋巴結是否轉移相關(x2=14.470、14.034,P＜0.05).GPC-1與CXCR7的暘性錶達與患者術後生存時間均無統計學意義(Log Rank =0.086、0.006,P均＜0.05).結論 GPC-1和CXCR7與胰腺癌的髮生髮展關繫密切,且與其侵襲轉移相關.二者的聯閤檢測對胰腺癌的診斷具有一定意義,同時也可對胰腺癌的侵襲轉移提供一項參攷依據.
목적 탐토린지선기순단백다당-1(glypicans-1,GPC-1)여추화인자수체CXCR7재이선암중적표체급림상의의.방법 응용면역조직화학방법검측52례이선암조직급30례정상이선조직중GPC-1여CXCR7적표체급상관성,전화수방통계예후정황.결과 이선암조직중GPC-1화CXCR7양성표체솔(56.79％、51.92％)균명현고우정상이선조직(x2=27.293、23.224,P균＜0.05),차이자적표체상호지간정정상관성(r=0.758,P＜0.001),동시GPC-1화CXCR7적양성표체여림파결시부전이상관(x2=14.470、14.034,P＜0.05).GPC-1여CXCR7적양성표체여환자술후생존시간균무통계학의의(Log Rank =0.086、0.006,P균＜0.05).결론 GPC-1화CXCR7여이선암적발생발전관계밀절,차여기침습전이상관.이자적연합검측대이선암적진단구유일정의의,동시야가대이선암적침습전이제공일항삼고의거.
Objective To investigate the expressions phosphatidylinositol protein polysaccharide-1 (glypican-1,GPC-1) and chemokine receptor CXCR7 in pancreatic carcinoma and their clinical significance.Methods The expression of GPC-1 (57.69％) and CXCR7(51.92％) was detected by immunohistochemical method in 52 cases of pancreatic cancer tissues and 30 cases of normal pancreatic tissues.All cases were followed up by phone calls.Results The positive expression of GPC-1 and CXCR7 in pancreatic carcinoma was much higher than that of normal pancreatic tissues (x2 =27.293,23.224,P ＜ 0.05).The expression of both molecules had positive correlation in pancreatic carcinoma (r =0.758,P ＜ 0.05).The expression of GPC-1 and CXCR7 were associated with lymph node metastasis (x2 =14.470,14.034,P ＜0.05).There were no statistical significance between the positive expression of the two indicators and the postoperative survival time of patients (Log Rank =0.086,0.006,P ＞ 0.05).Conclusion GPC-1 and CXCR7 are closely related with the occurrence and development of pancreatic cancer,and they are associated with the invasion and metastasis of pancreatic cancer.Combined detection may help the diagnosis of pancreatic cancer.
