CAJ | 학술논문

自噬是细胞内进行的一种“自我消化”的过程.在此过程中,受损的细胞结构、衰老的细胞器和变性蛋白被包裹在自噬小体中,运输到溶酶体被降解,参与细胞代谢.抗原递呈细胞(APCs)依赖自噬识别微生物,进而产生Ⅰ型干扰素.自噬不仅提供了递呈到MHC-Ⅱ类分子上的抗原肽,还参与了APC的MHC-Ⅰ类分子递呈途径.此外,自噬会降低免疫突触的稳定性.
자서시세포내진행적일충“자아소화”적과정.재차과정중,수손적세포결구、쇠로적세포기화변성단백피포과재자서소체중,운수도용매체피강해,삼여세포대사.항원체정세포(APCs)의뢰자서식별미생물,진이산생Ⅰ형간우소.자서불부제공료체정도MHC-Ⅱ류분자상적항원태,환삼여료APC적MHC-Ⅰ류분자체정도경.차외,자서회강저면역돌촉적은정성.
Autophagy is a self-digestion process,in which cytopasmic organelles or proteins are degraded in lysosome.Autophagy is required for antigen-presenting cells(APCs) to recognize intracellular danger signals and release type Ⅰ interferon.Autophagy not only provides a prominent source of antigens that can be loaded onto MHC-Ⅱ,but also participates in MHC-Ⅰ presentation pathway.In addition,attenuation in the formation of an immunologic synapse occurs along with the induction of autophagy.