国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2014年
3期
179-182
,共4页
炎症%MicroRNA%哮喘%类风湿关节炎%系统性红斑狼疮
炎癥%MicroRNA%哮喘%類風濕關節炎%繫統性紅斑狼瘡
염증%MicroRNA%효천%류풍습관절염%계통성홍반랑창
Inflammation%MicroRNA%Asthma%Rheumatoid arthritis%Systemic lupus erythematosus
Micro RNA (miRNA)是一类长度约为18～ 24个核苷酸的非编码小RNA,通过与靶mRNA的3端非编码区域结合,降解mRNA或阻止mRNA的翻译,发挥负性调节作用.炎症是具有血管系统的活体组织对损伤因子发生的防御性反应,可以清除进入机体的有害物质,但有些时候却对机体自身发生反应而造成损伤.目前发现多种miRNA参与炎症性疾病的发生、发展过程,因此研究与炎症性疾病有关的miRNA对这些疾病的诊断和治疗有重要的意义.
Micro RNA (miRNA)是一類長度約為18～ 24箇覈苷痠的非編碼小RNA,通過與靶mRNA的3耑非編碼區域結閤,降解mRNA或阻止mRNA的翻譯,髮揮負性調節作用.炎癥是具有血管繫統的活體組織對損傷因子髮生的防禦性反應,可以清除進入機體的有害物質,但有些時候卻對機體自身髮生反應而造成損傷.目前髮現多種miRNA參與炎癥性疾病的髮生、髮展過程,因此研究與炎癥性疾病有關的miRNA對這些疾病的診斷和治療有重要的意義.
Micro RNA (miRNA)시일류장도약위18～ 24개핵감산적비편마소RNA,통과여파mRNA적3단비편마구역결합,강해mRNA혹조지mRNA적번역,발휘부성조절작용.염증시구유혈관계통적활체조직대손상인자발생적방어성반응,가이청제진입궤체적유해물질,단유사시후각대궤체자신발생반응이조성손상.목전발현다충miRNA삼여염증성질병적발생、발전과정,인차연구여염증성질병유관적miRNA대저사질병적진단화치료유중요적의의.
MircoRNA (miRNA) is a class of small non-coding RNAs with 18 ～24 nucleotides in length and targets the 3' Untranslased region.miRNA plays an important role in negative regulation through promoting the degradation of mRNA or preventing the translation of mRNA.Inflammation is a defensive reaction occurring in living tissues with vascular system.On one hand,inflammation protects the tissue from damage by clearing harmful factors.On the other hand,inflammation can cause tissue damage by releasing the bioactive substances form inflammatory cells.It has been found that many miRNAs are involved in the occurrence and development of inflammatory diseases.Therefore,the studies on the inflammation-related miRNAs is important for the diagnosis and treatment of inflammatory diseases.
