CAJ | 학술논문

免疫治疗是抗肿瘤治疗的一项重要的辅助治疗手段.有效的激活自身抗肿瘤免疫系统对早期肿瘤的治疗有重要意义.与传统的应用靶点特异性抗体不同,研究者更倾向于对肿瘤组织内部的免疫应答过程进行深入研究,从而期望制定出更有效的肿瘤免疫治疗方案.肿瘤细胞处于不利于诱导抗肿瘤免疫应答的微环境中是肿瘤免疫治疗面临的主要困难之一.
면역치료시항종류치료적일항중요적보조치료수단.유효적격활자신항종류면역계통대조기종류적치료유중요의의.여전통적응용파점특이성항체불동,연구자경경향우대종류조직내부적면역응답과정진행심입연구,종이기망제정출경유효적종류면역치료방안.종류세포처우불리우유도항종류면역응답적미배경중시종류면역치료면림적주요곤난지일.
Immunotherapy is an important auxiliary anti-tumor treatment.It has important significance for treatment of early stage tumors by activating antitumor immune system effectively.Instead of novel checkpoint-blocking antibodies,recent insight into innate immune system may further improve cancer immunotherapy strategy and help to overcome the limitations of conventional strategies.A major hurdle for tumor immunotherapy is that the majority of tumor cells are located in an immunosuppressive tumor environment.This paper reviews the novel immunotherapeutic approaches for targeting established cancers.