国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2014年
4期
302-306
,共5页
γδT细胞%免疫应答%变应性疾病%哮喘%变应性鼻炎
γδT細胞%免疫應答%變應性疾病%哮喘%變應性鼻炎
γδT세포%면역응답%변응성질병%효천%변응성비염
γδT cells%Immune response%Allergic disease%Asthma%Allergic rhinitis
根据T细胞表面受体的不同,可将其分为αβT细胞和γδT细胞,γδT细胞在皮肤、肠黏膜、呼吸道、泌尿生殖系统黏膜中分布较多.作为连接固有免疫和适应性免疫的桥梁,γδT细胞在多种炎症性疾病、肿瘤和自身免疫疾病方面发挥重要作用.γδT细胞在不同的微环境中可表现出αβT胞亚群如细胞毒性T淋巴细胞(CTL)、Th1细胞、Th2细胞、Th17细胞、调节性T细胞(Treg)和抗原递呈细胞(APC)的功能,同时调节特异性IgE的产生和嗜酸性粒细胞的聚集.γδT细胞在变应性气道疾病的发生和发展中参与促炎、免疫调节和抑炎的过程,其不同亚群在变应性气道炎症中表现出不同的免疫调节功能.
根據T細胞錶麵受體的不同,可將其分為αβT細胞和γδT細胞,γδT細胞在皮膚、腸黏膜、呼吸道、泌尿生殖繫統黏膜中分佈較多.作為連接固有免疫和適應性免疫的橋樑,γδT細胞在多種炎癥性疾病、腫瘤和自身免疫疾病方麵髮揮重要作用.γδT細胞在不同的微環境中可錶現齣αβT胞亞群如細胞毒性T淋巴細胞(CTL)、Th1細胞、Th2細胞、Th17細胞、調節性T細胞(Treg)和抗原遞呈細胞(APC)的功能,同時調節特異性IgE的產生和嗜痠性粒細胞的聚集.γδT細胞在變應性氣道疾病的髮生和髮展中參與促炎、免疫調節和抑炎的過程,其不同亞群在變應性氣道炎癥中錶現齣不同的免疫調節功能.
근거T세포표면수체적불동,가장기분위αβT세포화γδT세포,γδT세포재피부、장점막、호흡도、비뇨생식계통점막중분포교다.작위련접고유면역화괄응성면역적교량,γδT세포재다충염증성질병、종류화자신면역질병방면발휘중요작용.γδT세포재불동적미배경중가표현출αβT포아군여세포독성T림파세포(CTL)、Th1세포、Th2세포、Th17세포、조절성T세포(Treg)화항원체정세포(APC)적공능,동시조절특이성IgE적산생화기산성립세포적취집.γδT세포재변응성기도질병적발생화발전중삼여촉염、면역조절화억염적과정,기불동아군재변응성기도염증중표현출불동적면역조절공능.
Based on the different expression of TCR chains,T cells can be divided into αβT cells and γδT cells.The vast majority of γδ T cells reside in epithelial layers of tissues such as skin,gut,lung and urinary tract.By acting as the bridge linking innate and adaptive immunity,γδT cells play vital functions in various inflammatory diseases,tumor,and autoimmune diseases.γδT cells,which display different functions similar to those of αβT cell subsets,such as CTLs,Th1/Th2 cells,Tregs,Th17 cells,and APCs,can regulate the production of specific IgE and the infiltration of eosuophils depending on specific microenvironment.γδT cells may exert pro-inflammatory,immunoregulatory,or anti-inflammatory roles in allergic airway diseases,different γδT subsets performing distinct functions.