CAJ | 학술논문

人类免疫缺陷病毒(HIV)表面包膜糖蛋白在其侵入宿主细胞过程中起着关键作用,同时也是免疫学研究和抗病毒药物设计的主要靶向.相关研究结果显示,高效表达并纯化HIV包膜蛋白需要结合HIV包膜蛋白物理和生物学特性,包括包膜蛋白分子大小、溶解度、电荷性质等特点.
인류면역결함병독(HIV)표면포막당단백재기침입숙주세포과정중기착관건작용,동시야시면역학연구화항병독약물설계적주요파향.상관연구결과현시,고효표체병순화HIV포막단백수요결합HIV포막단백물리화생물학특성,포괄포막단백분자대소、용해도、전하성질등특점.
Human immunodeficiency virus (HIV) envelope glycoprotein plays an important role in the process of virus entry.It' s also the major target of immunology research and anti-viral drug design.Some studies indicated that understanding the biophysical characters including molecular weight,solubility,and charges is necessary for high expressions and purifications of HIV glycoprotein.