CAJ | 학술논문

目的探讨白细胞介素-17A(IL-17A)在慢性牙周炎(CP)和类风湿性关节炎(RA)两者间的相关性.方法按纳入标准选择85名受试者分为四组:①CP组20例;②RA组23例;③RA伴CP组26例;④HP组16侧;记录牙周袋探诊深度(PD),临床附着丧失(CAL)和出血指数(BI),收集其晨起空腹血清并用滤纸条法收集受试者龈沟液样本,采用酶联免疫吸附试验法(ELISA)测定血清及龈沟液中IL-17A的水平.结果 RA+CP组中血清IL-17A水平(2216.0±1520.87)pg/mL与RA组[(851.59±975.81) pg/mL]、CP组[(1039.7±1004.83) pg/mL]和HP组[(209.48±50.02) pg/mL]差异有统计学意义,RA组和CP组中血清IL-17A水平分别与HP组的差异有统计学意义(P＜0.05),而龈沟液中的IL-17A水平在HP组[(356.75±69.07) pg/mL],RA组[(381.08±79.48) pg/mL],CP组[(397.82±108.53) pg/mL]以及RA+CP组[(414.71±103.09) pg/mL]间呈现升高趋势,但无统计学差异(P＞0.05).结论 IL-17A可能在慢性牙周炎和类风湿性关节炎相关性的研究中具有一定的意义.
목적 탐토백세포개소-17A(IL-17A)재만성아주염(CP)화류풍습성관절염(RA)량자간적상관성.방법 안납입표준선택85명수시자분위사조:①CP조20례;②RA조23례;③RA반CP조26례;④HP조16측;기록아주대탐진심도(PD),림상부착상실(CAL)화출혈지수(BI),수집기신기공복혈청병용려지조법수집수시자간구액양본,채용매련면역흡부시험법(ELISA)측정혈청급간구액중IL-17A적수평.결과 RA+CP조중혈청IL-17A수평(2216.0±1520.87)pg/mL여RA조[(851.59±975.81) pg/mL]、CP조[(1039.7±1004.83) pg/mL]화HP조[(209.48±50.02) pg/mL]차이유통계학의의,RA조화CP조중혈청IL-17A수평분별여HP조적차이유통계학의의(P＜0.05),이간구액중적IL-17A수평재HP조[(356.75±69.07) pg/mL],RA조[(381.08±79.48) pg/mL],CP조[(397.82±108.53) pg/mL]이급RA+CP조[(414.71±103.09) pg/mL]간정현승고추세,단무통계학차이(P＞0.05).결론 IL-17A가능재만성아주염화류풍습성관절염상관성적연구중구유일정적의의.
Objective This present study was to detect the role of IL-17A on the correlation between chronic periodontitis(CP) and rheumatoid arthritis(RA).Methods According to the inclusion criteria selected 85 subjects were detected into four groups:①20 patients with chronic periodontitis;②23 patients with the RA;②26 patients with CP and RA;④16 healthy numbers as the control group.The clinical periodontal parameters including probing depth (PD),clinical attachment loss(CA L),and bleeding index(BI) were examined,and the serum and GCF levels of IL-17A were measured by enzyme-linked immunosorbent assay(ELISA).Results The IL-17A levels in serum of patients with CP and RA[(2216.0 ± 1520.87)pg/mL]were significantly higher than the RA group [(851.59 ± 975.81) pg/mL],CP group [(1039.7 ± 1004.83) pg/mL] and the control group[(209.48 ± 50.02)pg/mL].Serum levels of IL-17A in CP group and RA group were significantly higher than the healthy control group(P ＜0.05).The IL-17A levels in GCF of in the HP group[(356.75 ±69.07)pg/mL],RA group[(381.08 ± 79.48) pg/mL]/CP group [(397.82 ± 108.53) pg/mL] and patients with CP and RA[(414.71 ± 103.09)pg/mL] showed a trend of increase,but no statistical difference (P ＞0.05).Conclusions IL-17A may have some significance in the study of the correlation between chronic periodontitis and rheumatoid arthritis.