CAJ | 학술논문

CXCL12介导的信号通路参与调节免疫细胞的活化和募集、造血干细胞的动员和归巢、新生血管形成、胚胎发育、肿瘤侵袭转移等过程.最近,CXCL12/CXCR4/CXCR7生物轴在胎盘植入和发育中的重要作用越来越受到关注.研究发现,CXCL12介导的信号通路参与调节胎盘滋养细胞的分化、增殖和侵袭,同时又可以趋化滋养细胞定向移动到蜕膜间质及血管周围,促进胎盘的植入、子宫-胎盘血管重塑和免疫耐受,进而维持妊娠的正常进行.深入理解CXCL12/CXCR4/CXCR7轴在胎盘滋养细胞中的作用机制,将有助于进一步认识胎盘植入的内在机制,为滋养细胞功能紊乱相关疾病的治疗提供新的思路.
CXCL12개도적신호통로삼여조절면역세포적활화화모집、조혈간세포적동원화귀소、신생혈관형성、배태발육、종류침습전이등과정.최근,CXCL12/CXCR4/CXCR7생물축재태반식입화발육중적중요작용월래월수도관주.연구발현,CXCL12개도적신호통로삼여조절태반자양세포적분화、증식화침습,동시우가이추화자양세포정향이동도세막간질급혈관주위,촉진태반적식입、자궁-태반혈관중소화면역내수,진이유지임신적정상진행.심입리해CXCL12/CXCR4/CXCR7축재태반자양세포중적작용궤제,장유조우진일보인식태반식입적내재궤제,위자양세포공능문란상관질병적치료제공신적사로.
CXCL12-induced signalling pathway plays an important role in regulating the activation and recruitment of immunocytes,mobilization and homing of hematopoietic stem cells,neo-angiogenesis,embryogenesis,invasion and metastasis of tumor cells.Rencently,the regulation of CXCL12/CXCR4/CXCR7 axis in placental implantation and development has aroused considerable attention.Related studies suggest that CXCL12-induced signalling can not only regulate differentiation,proliferation and invasion of placental trophoblast cells,but also induce trophoblast directed migration into decidual stromal tissues and blood vessels,promote placental implantation,uteroplacental vascular remodeling,materno-fetal immune tolerance,which further maintains the progression of pregnancy.A better understanding of the mechanism of CXCL12/CXCR4/CXCR7 axis in the maintenance of trophoblast functions may give insight into the process of placental implantation,hope fully offering a novel treatment strategy for trophoblast cells dysfunction-related diseases.