CAJ | 학술논문

皮肤树突状细胞(DC)作为重要的抗原提呈细胞,在机体免疫应答或自身耐受的发生中扮演着非常重要的角色.皮肤免疫系统中定居着多种DC亚群,主要包括表皮层中的郎格汉斯细胞(LC)与真皮层中的各种真皮DC亚群.健康皮肤中的DC亚群主要有表皮LC、真皮DC(dDC)和浆细胞DC(pDC),dDC又分为Langerin+ dDC及Langerin-dDC等.但在炎症性皮肤,如过敏性皮炎、银屑病等病变皮肤中则存在着炎症性DC亚群.DC由于其复杂的异质性群体,导致了其各亚群的特殊化功能.皮肤DC亚群的特殊化功能,为皮肤性疾病的临床治疗及新型疫苗的研发设计等都提供了良好的新策略.
피부수돌상세포(DC)작위중요적항원제정세포,재궤체면역응답혹자신내수적발생중분연착비상중요적각색.피부면역계통중정거착다충DC아군,주요포괄표피층중적랑격한사세포(LC)여진피층중적각충진피DC아군.건강피부중적DC아군주요유표피LC、진피DC(dDC)화장세포DC(pDC),dDC우분위Langerin+ dDC급Langerin-dDC등.단재염증성피부,여과민성피염、은설병등병변피부중칙존재착염증성DC아군.DC유우기복잡적이질성군체,도치료기각아군적특수화공능.피부DC아군적특수화공능,위피부성질병적림상치료급신형역묘적연발설계등도제공료량호적신책략.
Skin-derived dendritic cell (DC) are potent antigen-presenting cells with critical roles in both adaptive immunity and tolerance to self.The immune system of the skin has a network of resident DC consisting of epidermal Langerhans cells(LC) and various subsets of dermal DC.DC subsets of healthy skin mainly include the epidermal LC,dermal dendritic cell (dDC),and plasmacytoid dendritic cell (pDC).dDCs are divided into Langerin + dDC and Langerin-dDC.In inflammatory skin,such as lesions in the skin of atopic dermatitis and psoriasis,there are inflammatory DC subsets.Because of the heterogeneous features of DC,each subset of DC has specialized functions.Skin DC subsets with specialized features provide new strategies for the treatment of skin diseases and the development of new vaccines.