CAJ | 학술논문

多发性硬化(MS)是一种发生在中枢神经系统(CNS)内的慢性炎症性脱髓鞘疾病,具体病因及发病机制目前尚不明确.研究者认为,MS是在遗传易感性基础上,由环境因素及感染因素触发的髓鞘特异性CD4+T细胞攻击中枢神经系统髓鞘介导的自身免疫反应性疾病.然而近年研究表明,B细胞也参与了MS的发病及病程的调控,B细胞作为抗原递呈细胞(APCs)、产生促炎细胞因子和趋化因子以及分泌针对髓鞘和轴突的自身抗体都在MS发病机制中起重要作用.
다발성경화(MS)시일충발생재중추신경계통(CNS)내적만성염증성탈수초질병,구체병인급발병궤제목전상불명학.연구자인위,MS시재유전역감성기출상,유배경인소급감염인소촉발적수초특이성CD4+T세포공격중추신경계통수초개도적자신면역반응성질병.연이근년연구표명,B세포야삼여료MS적발병급병정적조공,B세포작위항원체정세포(APCs)、산생촉염세포인자화추화인자이급분비침대수초화축돌적자신항체도재MS발병궤제중기중요작용.
Multiple sclerosis (MS)is a chronic inflammatory demyelinating disease of central nervous system (CNS).The pathogenesis is still unclear.The mainstream view about the pathogenesis of MS is that MS is an autoimmune disease caused by the attacks of the myelin specific CD4 + T cells triggered by both environmental and inflammatory factors on the central nervous system myelin under the condition of genetic susceptibility.In recent years,studies have shown that B cells are involved in the pathogenesis of MS.As antigen presenting cells(APCs),B cells produce proinflammatory cytokines and chemokines and secret antibodies against myelin and axon.All of these elements are contributing to the pathogenesis of MS.