CAJ | 학술논문

机体在短时间内吸入了高浓度的一氧化碳毒性气体即可导致急性一氧化碳中毒,它是冬季较为常见的中毒性疾病之一,尤其在我国的北方地区发病率较高.此病在临床上的致残致死率极高,是急诊科常见的急危重症.患者多在经历一定时间的“假愈期”后发生一氧化碳中毒迟发性脑病,并且无法完全治愈,从而给社会和家庭造成严重的经济负担.但直到现在,一氧化碳中毒迟发性脑病的具体发病机制仍未完全阐明,并存在着多种学说.在此对一氧化碳中毒迟发性脑病发病机制的研究进行探讨,以期为其临床治疗提供新的思路及理论基础.
궤체재단시간내흡입료고농도적일양화탄독성기체즉가도치급성일양화탄중독,타시동계교위상견적중독성질병지일,우기재아국적북방지구발병솔교고.차병재림상상적치잔치사솔겁고,시급진과상견적급위중증.환자다재경력일정시간적“가유기”후발생일양화탄중독지발성뇌병,병차무법완전치유,종이급사회화가정조성엄중적경제부담.단직도현재,일양화탄중독지발성뇌병적구체발병궤제잉미완전천명,병존재착다충학설.재차대일양화탄중독지발성뇌병발병궤제적연구진행탐토,이기위기림상치료제공신적사로급이론기출.
The inhalation of high concentration of carbon monoxide within short period of time might cause acute carbon monoxide poisoning,which is common in emergency ward in winter,especially in north China.The rate of disability and mortality caused by acute carbon monoxide poisoning remains high.Delayed encephalopathy could happen after a period of "latent phase",which,however,can hardly be cured.This can also be serious economic burden to society and families.Till now,the exact pathogenesis of delayed encephalopathy after carbon monoxide poisoning remains to be illustrated.There are a variety of hypothesis for this disease.In this review,we discuss the research progress about the pathogenesis of this disorder in order to provide new ideas for its clinical treatment.