CAJ | 학술논문

经化学修饰的组织抗原,与正常组织成分有交叉反应的外来抗原、隔绝的体内自身成分及低分化的组织抗原等在一定条件下可刺激机体组织产生自身抗体.某些自身抗体因对系统性红斑狼疮(SLE)的判断具有高度特异性,已成为诊断SLE的血清指标或特异性抗体,有些自身抗体与疾病的活动性有相关性.因此,测定自身抗体有助于SLE的诊断,并对疾病的活动程度,观察治疗效果,指导临床用药具有重要的临床意义.
경화학수식적조직항원,여정상조직성분유교차반응적외래항원、격절적체내자신성분급저분화적조직항원등재일정조건하가자격궤체조직산생자신항체.모사자신항체인대계통성홍반랑창(SLE)적판단구유고도특이성,이성위진단SLE적혈청지표혹특이성항체,유사자신항체여질병적활동성유상관성.인차,측정자신항체유조우SLE적진단,병대질병적활동정도,관찰치료효과,지도림상용약구유중요적림상의의.
It is well known that chemical modified tissue antigens,foreign antigens with cross reactions to normal tissues,isolated components of the body,and poorly differentiated tissue antigens can induce the prodnltion of anto-antibodies in certain conditions.Some auto-antibodies,due to their high specificity,have been used to diagnose systemic lupus erythematosus.Besides,there is a correlation between some auto-antibodies and the active period of disease.Therefore,auto-antibody detection is helpful to diagnose systemic lupus erythematosus,to monitor disease activity or treatment effect,and to instruct clinical medication.