CAJ | 학술논문

硬皮病是一种以皮肤组织和内脏器官广泛纤维化、微血管改变和免疫反应异常为特征的复杂自身免疫性疾病,其发病机制尚不明确.近年来,较多研究结果显示硬皮病、类风湿和系统性红斑狼疮等自身免疫疾病具有类似的microRNA(miRNA)调控机制.进一步了解近年来自身免疫疾病中具有重要作用的miRNA以及硬皮病致病机制相关的miRNA可增进对其研究进展的理解.
경피병시일충이피부조직화내장기관엄범섬유화、미혈관개변화면역반응이상위특정적복잡자신면역성질병,기발병궤제상불명학.근년래,교다연구결과현시경피병、류풍습화계통성홍반랑창등자신면역질병구유유사적microRNA(miRNA)조공궤제.진일보료해근년래자신면역질병중구유중요작용적miRNA이급경피병치병궤제상관적miRNA가증진대기연구진전적리해.
Scleroderma is a kind of complex autoimmune disease characterized by extensive fibrosis of skin tissue,microvascular changes and abnormal immune reaction,its pathogenesis is not clear.Recent years,many researches showed that scleroderma,rheumatoid arthritis,systemic lupus erythematosus and some other autoimmune diseases share the similar mechanism of miRNA(miRNA) regulation.To further understand the important role of miRNA in autoimmune diseases and in pathogenesis of scleroderma can improve our understanding in the progress of miRNA.