CAJ | 학술논문

过敏性紫癜是儿童时期最常见的小血管炎.基因多态性与过敏性紫癜关系的研究对于从基因水平上揭示过敏性紫癜的发病机制和病人临床表现多样性的物质基础具有重要意义.有研究在认为,β-1,3半乳糖基转移酶(C1 GALT1)基因多态性与过敏性紫癜存在关联.目前C1 GALT1基因多态性与过敏性紫癜相关性的研究报道较少,因此就C1 GALT1基因多态性在过敏性紫癜的研究进展及对其他疾病的影响进行系统回顾和总结很有必要.
과민성자전시인동시기최상견적소혈관염.기인다태성여과민성자전관계적연구대우종기인수평상게시과민성자전적발병궤제화병인림상표현다양성적물질기출구유중요의의.유연구재인위,β-1,3반유당기전이매(C1 GALT1)기인다태성여과민성자전존재관련.목전C1 GALT1기인다태성여과민성자전상관성적연구보도교소,인차취C1 GALT1기인다태성재과민성자전적연구진전급대기타질병적영향진행계통회고화총결흔유필요.
Henoch-Sch(o)nlein purpura (HSP) is the most common small vasculitis in childhood.Study on the relationship between gene polymorphism and HSP is important in revealing the pathogenesis of HSP from gene level and interpreting the diversity of clinical manifestations.Studies have reported for the first time that beta 1,3 galactosyl base transferase (C1GALT1) gene polymorphisms is associated with Henoch-Sch(o)nlein purpura.There are only a few reports about the reltionship between C1 GALT1 gene polymorphism and HSP.Here we review the research progress about C1GALT1 gene polymorphism in HSP and its influence on other disease.