国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2014年
6期
507-514
,共8页
哮喘%气道高反应%2型固有淋巴样细胞%过敏
哮喘%氣道高反應%2型固有淋巴樣細胞%過敏
효천%기도고반응%2형고유림파양세포%과민
Asthma%Airway hyperreactivity%Type 2 innate lymphoid cells%Allergy
一直以来,2型辅助T淋巴细胞(Th2)被认为是通过分泌2型细胞因子介导哮喘患者气道慢性炎症反应的主要维持者.但其仍无法解释许多哮喘相关现象.近年来人们发现的2型固有淋巴样细胞(ILC2s)可以不依赖于固有免疫系统,在IL-25、IL-33或胸腺基质淋巴生成素(TSLP)等的作用下对外界多种刺激产生反应,分泌2型细胞因子,引发并维持2型免疫炎症反应,与人体抗寄生虫免疫、过敏相关疾病息息相关.
一直以來,2型輔助T淋巴細胞(Th2)被認為是通過分泌2型細胞因子介導哮喘患者氣道慢性炎癥反應的主要維持者.但其仍無法解釋許多哮喘相關現象.近年來人們髮現的2型固有淋巴樣細胞(ILC2s)可以不依賴于固有免疫繫統,在IL-25、IL-33或胸腺基質淋巴生成素(TSLP)等的作用下對外界多種刺激產生反應,分泌2型細胞因子,引髮併維持2型免疫炎癥反應,與人體抗寄生蟲免疫、過敏相關疾病息息相關.
일직이래,2형보조T림파세포(Th2)피인위시통과분비2형세포인자개도효천환자기도만성염증반응적주요유지자.단기잉무법해석허다효천상관현상.근년래인문발현적2형고유림파양세포(ILC2s)가이불의뢰우고유면역계통,재IL-25、IL-33혹흉선기질림파생성소(TSLP)등적작용하대외계다충자격산생반응,분비2형세포인자,인발병유지2형면역염증반응,여인체항기생충면역、과민상관질병식식상관.
The type 2 helper T lymphocytes (Th2) are always considered to be the one that secret the type 2 cytokines and maintain the chronic inflammation of the airways of asthmatic patients.It still cannot explain many asthma-related phenomena.In recent years,it was found that on response to cytokines such as interleukin-25 and interleukin-33,the type 2 innate lymphoid cells (ILC2s),independent of the acquired immunity system,can produce type 2 cytokines.These cells can also initiate and maintain the type 2 inflammation in human anti-parasite immunity and allergy-related diseass.ILC2s can respond to a variety of environmental stimuli.This review focuses on how ILC2s are found,their histological distribution,immunological properties,and their roles in asthma.
