CAJ | 학술논문

背景全麻药物作用于中枢神经系统的多种神经递质和受体靶点,而这些又恰恰是神经突触可塑性相关机制中的重要成分或结构,通过调节突触可塑性进而对学习记忆功能产生广泛而多样的作用. 目的推进对全麻药物麻醉机理的认识. 内容分析全麻药物对大脑突触可塑性影响的研究进展趋向为临床麻醉药物的合理使用、减少术中知晓和术后认知功能障碍等相关并发症的发生提供科学依据.
배경 전마약물작용우중추신경계통적다충신경체질화수체파점,이저사우흡흡시신경돌촉가소성상관궤제중적중요성분혹결구,통과조절돌촉가소성진이대학습기억공능산생엄범이다양적작용. 목적 추진대전마약물마취궤리적인식. 내용 분석전마약물대대뇌돌촉가소성영향적연구진전 추향 위림상마취약물적합리사용、감소술중지효화술후인지공능장애등상관병발증적발생제공과학의거.
Background Many neurotransmitters and relative receptors are involved in the complicated mechanisms of general anesthetics,which are also the modulative targets of synaptic plasticity pathways,leading to various effects on learning and memory in central nervous system.Objective To review the relationship between general anesthetics and synaptic plasticity.Content A growing number of studies have resulted in some reasonable explanations about the mechanisms of general anesthetics.Trend It would be useful for the development and application of suitable general anesthetics and reducing the incidence of intraoperative awareness and postoperative cognitive dysfunction.