CAJ | 학술논문

背景常用抗抑郁药具有起效慢、有效率低等缺点,氯胺酮静脉注射则可产生快速、确切的抗抑郁效果. 目的综述氯胺酮抗抑郁作用临床研究进展. 内容总结氯胺酮用于不同抑郁患者的抗抑郁效果,阐述可能的作用机制及副作用. 趋向氯胺酮作为抗抑郁研究的重要新型工具药,其抗抑郁治疗方案及相关作用机制尚需进一步研究.
배경 상용항억욱약구유기효만、유효솔저등결점,록알동정맥주사칙가산생쾌속、학절적항억욱효과. 목적 종술록알동항억욱작용림상연구진전. 내용 총결록알동용우불동억욱환자적항억욱효과,천술가능적작용궤제급부작용. 추향 록알동작위항억욱연구적중요신형공구약,기항억욱치료방안급상관작용궤제상수진일보연구.
Background Commonly used antidepressants have some defects including the delayed onset time of action and the low rate of effectiveness,whereas ketamine may exert a rapid and efficacious antidepressant effect.Objective This article reviews the clinical research advances in the antidepressant effect of ketamine.Content To summarize the antidepressant effects of ketamine in various depression and to elucidate the potential mechanisms of action and adverse reactions.Trend Further investigations regarding the antidepressant therapeutic protocol and the relevant mechanisms of action were needed on ketamine as a important new type of antidepressant.