CAJ | 학술논문

背景给予缺血性心肌吸入麻醉药后处理(inhaled anesthetics-induced postconditioning,APO)产生了极强的保护作用,该作用机制复杂,涉及到一系列细胞信号转导反应. 目的就APO心肌保护涉及的主要细胞信号通路及效应器进行回顾和总结. 内容大量研究证实APO通过激活再灌注损伤补救激酶通路,经由蛋白激酶C、一氧化氮(NO)等中间因子的级联放大,抑制了再灌注期间活性氧自由基爆发,降低了细胞内钙超载,从而发挥抑制线粒体依赖性心肌细胞凋亡、减少心肌缺血/再灌注(ischemia/reperfusion,I/R)损伤的作用. 趋向明晰APO心肌保护作用的主要细胞信号通路及其下游效应器,有助于发现临床上治疗心肌I/R损伤的新靶点,优化APO心肌保护方案,具有重要的转化医学意义.
배경 급여결혈성심기흡입마취약후처리(inhaled anesthetics-induced postconditioning,APO)산생료겁강적보호작용,해작용궤제복잡,섭급도일계렬세포신호전도반응. 목적 취APO심기보호섭급적주요세포신호통로급효응기진행회고화총결. 내용 대량연구증실APO통과격활재관주손상보구격매통로,경유단백격매C、일양화담(NO)등중간인자적급련방대,억제료재관주기간활성양자유기폭발,강저료세포내개초재,종이발휘억제선립체의뢰성심기세포조망、감소심기결혈/재관주(ischemia/reperfusion,I/R)손상적작용. 추향 명석APO심기보호작용적주요세포신호통로급기하유효응기,유조우발현림상상치료심기I/R손상적신파점,우화APO심기보호방안,구유중요적전화의학의의.
Background Inhaled anesthetics postconditioning (APO) exerts potent protection against myocardial ischemia/reperfusion (I/R) injury.This cardioprotection of APO involves complexcell signaling pathways.Objective Here we retrospectively summarized cell signaling pathways and downstream effectors in volatile anesthetic postconditioning-induced cardioprotection.Contents A great deal of studies show that APO exerts cardioprotection against I/R injury through activating reperfusion injury salvage kinase pathways,the following protein kinase C and nitric oxide cascades,as well as inhibiting reactive oxygen species overproduction,cellular Ca2+ overload,and mitochondrial apoptosis.Trend To clarify the key cell signaling pathway and downstream effectors in the cardioprotection of APO is helpful to find a new potential target for treatment of myocardial I/R injury,which is important to optimize the APO strategy against myocardial I/R injury and has translational medical meaning.