国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2013年
2期
182-185
,共4页
NF-E2相关因子2%抗氧化反应元件%氧化应激%肝脏保护
NF-E2相關因子2%抗氧化反應元件%氧化應激%肝髒保護
NF-E2상관인자2%항양화반응원건%양화응격%간장보호
Nuclear factor elytroid 2-related factor 2%Antioxidant response element%Oxidative stress%Liver protection
背景 随着肝脏外科手术尤其是肝脏移植手术的发展,以转录因子NF-E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)与抗氧化反应元件(antioxidant response element,ARE)抗氧化应激系统在肝脏损伤中的作用倍受关注. 目的 分析并总结Nrf2-ARE抗氧化系统在肝脏保护各方面的文献资料. 内容 简要介绍Nrf2,ARE的结构及其信号路径；综述了Nrf2基因缺失、Nrf2药物激活、Nrf2基因激活3类模型小鼠与野生小鼠肝脏对氧化应激的耐受性比较的结果. 趋向 Nrf2-ARE信号路径在肝脏中有一定的保护作用,为临床提供了新的思路.
揹景 隨著肝髒外科手術尤其是肝髒移植手術的髮展,以轉錄因子NF-E2相關因子2(nuclear factor erythroid 2-related factor 2,Nrf2)與抗氧化反應元件(antioxidant response element,ARE)抗氧化應激繫統在肝髒損傷中的作用倍受關註. 目的 分析併總結Nrf2-ARE抗氧化繫統在肝髒保護各方麵的文獻資料. 內容 簡要介紹Nrf2,ARE的結構及其信號路徑；綜述瞭Nrf2基因缺失、Nrf2藥物激活、Nrf2基因激活3類模型小鼠與野生小鼠肝髒對氧化應激的耐受性比較的結果. 趨嚮 Nrf2-ARE信號路徑在肝髒中有一定的保護作用,為臨床提供瞭新的思路.
배경 수착간장외과수술우기시간장이식수술적발전,이전록인자NF-E2상관인자2(nuclear factor erythroid 2-related factor 2,Nrf2)여항양화반응원건(antioxidant response element,ARE)항양화응격계통재간장손상중적작용배수관주. 목적 분석병총결Nrf2-ARE항양화계통재간장보호각방면적문헌자료. 내용 간요개소Nrf2,ARE적결구급기신호로경；종술료Nrf2기인결실、Nrf2약물격활、Nrf2기인격활3류모형소서여야생소서간장대양화응격적내수성비교적결과. 추향 Nrf2-ARE신호로경재간장중유일정적보호작용,위림상제공료신적사로.
Background With the development of liver surgery,especially in the liver transplants,more attention was focus on the transcription factor NF-E2-related factor 2 (nuclear factor elytroid 2-related factor 2,Nrf2) and antioxidant response element (ARE) anti-oxidative stress system effect on the liver injury.Objective Literatures about the Nrf2-ARE antioxidant system protection in the liver were analyzed and summarized.Content Nrf2,ARE structure and the signal path and comparisons of three kinds of model mice-Nrf2 gene deletion,Nrf2 drugs activation,Nrf2 gene activation-with wild-type mice on liver tolerance to oxidative stress were briefly reviewed.Trend Nrf2-ARE signaling pathway in the liver has a protective effec for clinical application.
