CAJ | 학술논문

背景学习记忆形成的确切机制仍不清楚,现有的研究多集中在学习记忆的调控因子方面,尤其是正调控因子方面.近年来,学习记忆负调控因子在学习记忆的正确形成与维持中的作用引起了人们的重视. 目的综述负调控因子在学习记忆形成与维持中的作用及意义. 内容学习记忆的负调控因子主要有蛋白磷酸酶、磷酸二酯酶、转录调节因子、组蛋白去乙酰化酶及hippyragranin(HGN)基因等,它们在细胞膜受体、胞质内信号转导通路级联成分、胞核内基因表达的转录调节以及细胞生长发育等多个层次调控学习记忆. 趋向对学习记忆负调控因子和学习记忆正/负调控平衡的深入研究将有助于人们对学习记忆形成与维持机制的理解,并有助于寻找有效干预措施.
배경 학습기억형성적학절궤제잉불청초,현유적연구다집중재학습기억적조공인자방면,우기시정조공인자방면.근년래,학습기억부조공인자재학습기억적정학형성여유지중적작용인기료인문적중시. 목적 종술부조공인자재학습기억형성여유지중적작용급의의. 내용 학습기억적부조공인자주요유단백린산매、린산이지매、전록조절인자、조단백거을선화매급hippyragranin(HGN)기인등,타문재세포막수체、포질내신호전도통로급련성분、포핵내기인표체적전록조절이급세포생장발육등다개층차조공학습기억. 추향 대학습기억부조공인자화학습기억정/부조공평형적심입연구장유조우인문대학습기억형성여유지궤제적리해,병유조우심조유효간예조시.
Background The exact mechanism of learning and memory is still unclear.The existing researches mainly focused on learning and memory regulatory factors,especially on positive regulatory factors.In recent years,the roles of learning and memory negative regulatory factors in correct forming and maintaining of the learning and memory have attracted most attentions.Objective Summary of the role of and significance learning and memory negative regulatory factors in the mechanism of learning and memory formation and maintainance.Content The negative regulatory factors of learning and memory mainly include protein phosphatase,cyclic nucleotide phosphodiesterases,transcriptional regulation factor,histone deacetylases,hippyragranin(HGN) gene and so on.They regulate learning and memory in multiple levels including the cell membrane receptors,cytoplasmic signal transduction cascade composition,transcriptional regulation of gene expression in the nucleus and cell growth and development.Trend In-depth study of learning and memory negative regulatory factors and the balance between learning and memory positive/negative regulation contribute to our understanding of the mechanism of learning and memory formation and maintainance,and searching for effective interventions.