国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2013年
6期
571-574
,共4页
Mitsugumin 53%细胞膜修复%心肌保护
Mitsugumin 53%細胞膜脩複%心肌保護
Mitsugumin 53%세포막수복%심기보호
Mitsugumin 53%Cell membrane repair%Myocardial protection
背景 Mitsugumin 53 (MG53)是一种新发现的骨骼肌和心肌特异性表达的tripartite motif family proteins (TRIM)家族蛋白成员,近来提出MG53参与细胞膜修复与心肌保护过程. 目的 探讨MG53参与肌细胞膜修复的分子机制及在心肌细胞中的作用. 内容 拟通过MG53在肌细胞膜修复过程的分子机制、参与心脏的缺血预适应/后适应保护机制等方面来描述MG53的作用. 趋势 新近发现的MG53在心肌保护中的价值需要进一步研究,为疾病的诊治提供新方法.
揹景 Mitsugumin 53 (MG53)是一種新髮現的骨骼肌和心肌特異性錶達的tripartite motif family proteins (TRIM)傢族蛋白成員,近來提齣MG53參與細胞膜脩複與心肌保護過程. 目的 探討MG53參與肌細胞膜脩複的分子機製及在心肌細胞中的作用. 內容 擬通過MG53在肌細胞膜脩複過程的分子機製、參與心髒的缺血預適應/後適應保護機製等方麵來描述MG53的作用. 趨勢 新近髮現的MG53在心肌保護中的價值需要進一步研究,為疾病的診治提供新方法.
배경 Mitsugumin 53 (MG53)시일충신발현적골격기화심기특이성표체적tripartite motif family proteins (TRIM)가족단백성원,근래제출MG53삼여세포막수복여심기보호과정. 목적 탐토MG53삼여기세포막수복적분자궤제급재심기세포중적작용. 내용 의통과MG53재기세포막수복과정적분자궤제、삼여심장적결혈예괄응/후괄응보호궤제등방면래묘술MG53적작용. 추세 신근발현적MG53재심기보호중적개치수요진일보연구,위질병적진치제공신방법.
Background Mitsugumin 53(MG53),specially expressed in skeletal and cardiac muscle,is a newly discovered member of Tripartite Motif Family Proteins.Objective Explore the molecular mechanisms of the MG53 involved in the muscle membrane repair and myocardial protection.Content Discuss the role of MG53 in following details:the molecular mechanisms of the MG53 involved in the muscle membrane repair and the role in myocardial ischemic preconditioning and postconditioning protection mechanisms.Trend The value of newly discovered MG53 in myocardial protection needs further study,it will provide new methods for the diagnosis and treatment in heart disease.
