CAJ | 학술논문

背景氯胺酮是一种临床常见的静脉麻醉药,尤其在小儿麻醉领域中占据着独特的地位.由于此药的一些副作用限制了它的运用,曾淡出临床医生的视野.近年来,氯胺酮又被陆续报道出有许多其他的药效,譬如:减少痛觉过敏、神经保护、抗抑郁、抗癌和抗炎等. 目的综述近年来发现的氯胺酮的非麻醉应用. 内容回顾氯胺酮的镇痛作用、神经保护作用、抗抑郁作用、抗肿瘤和抗炎作用及其机制. 趋向为临床上氯胺酮的应用提供新的思路.
배경 록알동시일충림상상견적정맥마취약,우기재소인마취영역중점거착독특적지위.유우차약적일사부작용한제료타적운용,증담출림상의생적시야.근년래,록알동우피륙속보도출유허다기타적약효,비여:감소통각과민、신경보호、항억욱、항암화항염등. 목적 종술근년래발현적록알동적비마취응용. 내용 회고록알동적진통작용、신경보호작용、항억욱작용、항종류화항염작용급기궤제. 추향 위림상상록알동적응용제공신적사로.
Background Ketamine is a common clinical intravenous anaesthetics,which occupies a unique niche in infantile anesthesiology.But the side effects restricted the use of ketamine.Katamine faded out clinician perspective at one time.While in the past few years,ketamine was reported to have several new clinically beneficial properties such as prevention of hyperalgesia,neuroprotection,anti-depression,anti-tumour,anti-inflammatory and so on.Objective The non-anesthetic use of ketamine was reviewed.Content This article reviewed the analgesic effect of ketamine,neuroprotectiive effect,anti-depression,anti-tumour and anti-inflammatory effect and its mechanism.Trend To provide new ideas for the clinical use of ketamine.