CAJ | 학술논문

背景锌作为重要信号分子,参与了缺血预处理(ischemic preconditioning,IPC)、缺血后处理以及药物预处理心肌保护效应,其具体机制还不是很清楚. 目的探讨锌在预处理心肌保护中的作用及其机制. 内容从锌的基本作用、在预处理心肌保护中的作用及其机制方面进行文献综述.锌可能通过Zn2+-磷脂酰肌醇3-激酶-蛋白激酶B-糖原合成激酶-3β(Zn2+-PI3K-Akt-GSK-3β)和一氧化氮-环单磷酸鸟苷-蛋白激酶G-Zn2+-细胞外信号调节激酶(NO-cGMP-PKG-Zn2+-ERK)信号途径,以及介导产生保护性活性氧(reactive oxygen species,ROS)信号分子等机制来参与预处理心肌保护作用. 趋向锌与线粒体之间的相互作用机制将越来越受重视,尤其是与线粒体bc1复合体相互作用以及与保护性ROS信号生成之间的关系.
배경 자작위중요신호분자,삼여료결혈예처리(ischemic preconditioning,IPC)、결혈후처리이급약물예처리심기보호효응,기구체궤제환불시흔청초. 목적 탐토자재예처리심기보호중적작용급기궤제. 내용 종자적기본작용、재예처리심기보호중적작용급기궤제방면진행문헌종술.자가능통과Zn2+-린지선기순3-격매-단백격매B-당원합성격매-3β(Zn2+-PI3K-Akt-GSK-3β)화일양화담-배단린산조감-단백격매G-Zn2+-세포외신호조절격매(NO-cGMP-PKG-Zn2+-ERK)신호도경,이급개도산생보호성활성양(reactive oxygen species,ROS)신호분자등궤제래삼여예처리심기보호작용. 추향 자여선립체지간적상호작용궤제장월래월수중시,우기시여선립체bc1복합체상호작용이급여보호성ROS신호생성지간적관계.
Background As an important signaling molecule,zinc takes part in ischemic preconditioning,postconditioning and pharmacological preconditioning,but the specific mechanisms remain unclear.Objective To review the role of zinc in myocardial preconditioning and its potential mechanisms.Content Covering the basic function of zinc,the role of zinc in myocardial preconditioning and its potential mechanisms.The underlying mechanisms may refer to the two main signaling pathways including Zn2+-PI3K-Akt-GSK-3β and NO-cGMP-PKG-Zn2+-ERK,as well as that involved in increasing the production of protective reactive oxygen species (ROS).Trend The mechanisms for the interaction between zinc and mitochondrion will draw more and more attention,especially the interaction of zinc with mitochondrial bc1 complex and the relationship between zinc and the production of protective ROS signals.