CAJ | 학술논문

背景血管的通透性主要由跨细胞途径和细胞旁途径两部分组成.在炎症反应过程中,细胞旁途径是增加血管通透性的主要因素.紧密连接(tight junction,TJ)是细胞旁途径的重要组成部分,破坏它将导致细胞通透性的增加. 目的分析TJ的信号机制,更好地理解其保护血管屏障的功能. 内容对影响TJ的几个重要的信号通路进行综述,揭示其影响细胞通透性的信息传递和调控作用. 趋向 TJ的完整性可以抑制水肿液的产生,今后将进一步探索其在炎症性疾病中的具体应用,从而更好地诊断疾病,预测疾病的发生发展及疗效.
배경 혈관적통투성주요유과세포도경화세포방도경량부분조성.재염증반응과정중,세포방도경시증가혈관통투성적주요인소.긴밀련접(tight junction,TJ)시세포방도경적중요조성부분,파배타장도치세포통투성적증가. 목적 분석TJ적신호궤제,경호지리해기보호혈관병장적공능. 내용 대영향TJ적궤개중요적신호통로진행종술,게시기영향세포통투성적신식전체화조공작용. 추향 TJ적완정성가이억제수종액적산생,금후장진일보탐색기재염증성질병중적구체응용,종이경호지진단질병,예측질병적발생발전급료효.
Background Vascular permeability is primarily composed of transcellular and paracellular pathways,with the latter being a major contributor to the increasing of vascular permeability in the process of inflammation.Tight junction (TJ) is the important component of paracellular pathways.The destruction of TJ will induce the increasing of vascular permeability.Objective This article is to analyze signaling mechanisms of TJ and to explain its function of protecting blood vessels barriers.Content This article reviewed several important signaling mechanisms which affect the TJ,revealed its information transfer and regulation of cell permeability.Trend The integrity of TJ can restrain the generation of edema fluid and future research will focus on its specific application in inflammatory disease,in order to diagnose better and predict development and therapeutic effect of disease.