CAJ | 학술논문

背景环氧化酶(cyclooxygenase,COX)-2抑制剂在多模式镇痛中发挥重要作用,且逐渐被应用到各新领域.目的阐述帕瑞昔布钠在围术期镇痛应用的可行性. 内容现就帕瑞昔布钠的药理学作用、围术期镇痛应用、新领域探索及注意事项展开综述. 趋向治疗剂量内帕瑞昔布钠作用于围术期疼痛有效,新领域的探索还待后续研究.
배경 배양화매(cyclooxygenase,COX)-2억제제재다모식진통중발휘중요작용,차축점피응용도각신영역.목적 천술파서석포납재위술기진통응용적가행성. 내용 현취파서석포납적약이학작용、위술기진통응용、신영역탐색급주의사항전개종술. 추향 치료제량내파서석포납작용우위술기동통유효,신영역적탐색환대후속연구.
Background Cyclooxygenase (Cox-2) inhibitors play an important part in multimodal analgesia,and are gradually puted use into some new fields.Objective To elaborate the feasibility of the use of parecoxib sodium in perioperative analgesia.Content This article focus on the pharmacology,the use in perioperative analgesia,explorations in new fields and the notes of parecoxib sodium.Trend Parecoxib sodium is effective in perioperative analgesia under standard treatment doses,further studies are needed to explore its generalization in new fields.