CAJ | 학술논문

背景 B细胞主要特征为产生抗体和细胞因子,并且具有抗原提呈功能.调节性B细胞作为B细胞的一个重要的特殊功能性亚群,在小鼠自身免疫和炎症模型中起发病和调节作用. 目的探讨有关调节性B细胞作用机制的最新研究进展. 内容描述调节性B细胞特点和在自身免疫性疾病和肿瘤中的作用. 趋向目前仍不能确定调节性B细胞具体的表型,在每一种的病理情况下,调节性B细胞可能存在不同的复杂的细胞网络,控制其调节的活性可能是治疗自身免疫性疾病和肿瘤的一种新方法.
배경 B세포주요특정위산생항체화세포인자,병차구유항원제정공능.조절성B세포작위B세포적일개중요적특수공능성아군,재소서자신면역화염증모형중기발병화조절작용. 목적 탐토유관조절성B세포작용궤제적최신연구진전. 내용 묘술조절성B세포특점화재자신면역성질병화종류중적작용. 추향 목전잉불능학정조절성B세포구체적표형,재매일충적병리정황하,조절성B세포가능존재불동적복잡적세포망락,공제기조절적활성가능시치료자신면역성질병화종류적일충신방법.
Background B cells are typically characterized by the ability to produce antibodies and cytokines,also possess the ability to present agents.Regulatory B cells,as the B cell functionally distinct subset,performing both pathogenic and regulatory role in several murine models of autoimmunity and inflammation.Objective To discuss the most recently progress in the role of regulatory B cells.Content This paper sums up the characters of regulatory B cells,and the functions of regulatory B cells in the autoimmune diseases and tumor.Trend Currently,the exact identity and origin of the regulatory B cells remains elusive.The complex cellular network may differ for each pathology.Control of regulatory activity would be an alternative therapy for autoimmune diseases and tumors.