国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
6期
361-364,375
,共5页
糖尿病肾病%牙周病%2型糖尿病
糖尿病腎病%牙週病%2型糖尿病
당뇨병신병%아주병%2형당뇨병
Diabetic nephropathy%Periodontal disease%Type 2 diabetes mellitus
目的 探讨糖尿病肾病与牙周病的相关性.方法 选取新入院的2型糖尿病患者200例,根据24 h尿微量白蛋白(MAU)水平分为3组:A组(正常蛋白尿组):MAU＜ 30 mg/24 h；B组(早期糖尿病肾病组):MAU 30～300 mg/24 h；C组(临床糖尿病肾病组):MAU＞ 300 mg/24 h.采集患者的一般临床指标及反映肾功能的指标血肌酐(Scr)、血尿素氮(BUN),计算估算的肾小球滤过率(eGFR),并对患者进行牙周检查,检查指标包括出血指数(BI)、牙周探诊深度(PD)、临床附着丧失(CAL)及缺牙数目.结果 (1)随着MAU水平升高,BI、PD、CAL及缺牙数目均明显增加(均P＜0.00l).(2) Logistic回归分析显示,PD、CAL及缺牙数目是糖尿病肾病发生的独立危险因素(P＜0.05或0.01).(3) Scr与BI、PD、CAL及缺牙数目均呈正相关(r分别为0.212、0.267、0.324、0.316,均P＜0.01)；BUN与BI、PD、CAL及缺牙数目均呈正相关(r分别为0.147、0.168、0.268、0.334,均P＜0.05)；eGFR与BI无相关性(r=-0.137,P＞0.05),而与PD、CAL及缺牙数目均呈负相关(r分别为-0.213、-0.284、-0.339,均P＜0.01).结论 糖尿病肾病与牙周病关系密切,牙周及牙齿缺失状况可以作为早期发现糖尿病肾病的线索.
目的 探討糖尿病腎病與牙週病的相關性.方法 選取新入院的2型糖尿病患者200例,根據24 h尿微量白蛋白(MAU)水平分為3組:A組(正常蛋白尿組):MAU＜ 30 mg/24 h；B組(早期糖尿病腎病組):MAU 30～300 mg/24 h；C組(臨床糖尿病腎病組):MAU＞ 300 mg/24 h.採集患者的一般臨床指標及反映腎功能的指標血肌酐(Scr)、血尿素氮(BUN),計算估算的腎小毬濾過率(eGFR),併對患者進行牙週檢查,檢查指標包括齣血指數(BI)、牙週探診深度(PD)、臨床附著喪失(CAL)及缺牙數目.結果 (1)隨著MAU水平升高,BI、PD、CAL及缺牙數目均明顯增加(均P＜0.00l).(2) Logistic迴歸分析顯示,PD、CAL及缺牙數目是糖尿病腎病髮生的獨立危險因素(P＜0.05或0.01).(3) Scr與BI、PD、CAL及缺牙數目均呈正相關(r分彆為0.212、0.267、0.324、0.316,均P＜0.01)；BUN與BI、PD、CAL及缺牙數目均呈正相關(r分彆為0.147、0.168、0.268、0.334,均P＜0.05)；eGFR與BI無相關性(r=-0.137,P＞0.05),而與PD、CAL及缺牙數目均呈負相關(r分彆為-0.213、-0.284、-0.339,均P＜0.01).結論 糖尿病腎病與牙週病關繫密切,牙週及牙齒缺失狀況可以作為早期髮現糖尿病腎病的線索.
목적 탐토당뇨병신병여아주병적상관성.방법 선취신입원적2형당뇨병환자200례,근거24 h뇨미량백단백(MAU)수평분위3조:A조(정상단백뇨조):MAU＜ 30 mg/24 h；B조(조기당뇨병신병조):MAU 30～300 mg/24 h；C조(림상당뇨병신병조):MAU＞ 300 mg/24 h.채집환자적일반림상지표급반영신공능적지표혈기항(Scr)、혈뇨소담(BUN),계산고산적신소구려과솔(eGFR),병대환자진행아주검사,검사지표포괄출혈지수(BI)、아주탐진심도(PD)、림상부착상실(CAL)급결아수목.결과 (1)수착MAU수평승고,BI、PD、CAL급결아수목균명현증가(균P＜0.00l).(2) Logistic회귀분석현시,PD、CAL급결아수목시당뇨병신병발생적독립위험인소(P＜0.05혹0.01).(3) Scr여BI、PD、CAL급결아수목균정정상관(r분별위0.212、0.267、0.324、0.316,균P＜0.01)；BUN여BI、PD、CAL급결아수목균정정상관(r분별위0.147、0.168、0.268、0.334,균P＜0.05)；eGFR여BI무상관성(r=-0.137,P＞0.05),이여PD、CAL급결아수목균정부상관(r분별위-0.213、-0.284、-0.339,균P＜0.01).결론 당뇨병신병여아주병관계밀절,아주급아치결실상황가이작위조기발현당뇨병신병적선색.
Objective To explore the relationship between diabetic nephropathy(DN) and periodontal disease.Methods 200 new hospitalized patients with type 2 diabetes were enrolled.Subjects were further divided into three groups according to the level of microalbuminuria(MAU):group A (normal albuminuria group):MAU ＜30 mg/24 h,group B (early-stage DN group):MAU 30 ～300 mg/24 h,group C (clinical DN group):MAU ＞300 mg/24 h.The clinical data and kidney function markers including serum creatinine (Scr),blood urea nitrogen(BUN) were collected,estimated glomerular filtration rate(eGFR) were calculated and the periodontal conditions including the periodontal pocket depth (PD),bleeding index (BI),clinical attachment loss (CAL) and tooth loss were detected.Results (1) BI,PD,CAL and tooth loss were increasing with MAU (P ＜ 0.001).(2) Logistic analysis showed that PD,GI and CAL were the independent risk factors of DN(P ＜0.05 or 0.01).(3) Scr was positively correlated with BI,PD,CAL and tooth loss (r =0.212,0.267,0.324,0.316 respectively,P ＜0.01);BUN was positively correlated with BI,PD,CAL and tooth loss (r =0.147,0.168,0.268,0.334 respectively,P ＜ 0.05) and eGFR was not correlated with BI (r =-0.137,P ＞ 0.05),but negatively correlated with PD,CAL and tooth loss (r =-0.213,-0.284,-0.339 respectively,P ＜ 0.01).Conclusion There might be a correlation between periodontal disease and DN.The periodontal disease and tooth loss could be an indicator for early detection of DN.
