CAJ | 학술논문

分泌型卷曲相关蛋白5(Sfrp5)是分泌型卷曲相关蛋白家族(Sfrs)的一员,作为Wnt信号通路的抑制剂,可通过调控Wnt信号转导通路参与胚胎发育、细胞增殖及肿瘤生成等过程.最近研究表明Sfrp5是一种脂肪细胞因子,前体脂肪细胞分化成熟过程中被强烈诱导表达；其也可通过阻断脂肪组织Wnt信号通路,促进脂肪细胞分化,增加饮食诱导的肥胖.Sfrp5表达水平与肥胖和糖尿病相关,通过减弱非经典Wnt信号转导通路而减轻机体胰岛素抵抗.深入研究Sfrp5的生物学功能,将为治疗肥胖及相关代谢性疾病提供新的机会.
분비형권곡상관단백5(Sfrp5)시분비형권곡상관단백가족(Sfrs)적일원,작위Wnt신호통로적억제제,가통과조공Wnt신호전도통로삼여배태발육、세포증식급종류생성등과정.최근연구표명Sfrp5시일충지방세포인자,전체지방세포분화성숙과정중피강렬유도표체；기야가통과조단지방조직Wnt신호통로,촉진지방세포분화,증가음식유도적비반.Sfrp5표체수평여비반화당뇨병상관,통과감약비경전Wnt신호전도통로이감경궤체이도소저항.심입연구Sfrp5적생물학공능,장위치료비반급상관대사성질병제공신적궤회.
Secreted frizzled related protein 5 (Sfrp5)is a member of the Sfrps family,as an inhibitor of the Wnt signal transduction pathway,which regulates the Wnt signal transduction pathway and affects embryonic development,cell proliferation and tumorigenesis.The latest researches show that Sfrp5 is a new adipokine.Expression of Sfrp5 is strongly increased when preadipocyte differentiates into mature adipocyte.Sfrp5 also can inhibit the Wnt signal transduction pathway of adipose tissue,promote adipocyte differentiation,increase diet induced obesity.The level of Sfrp5 is related to obesity and diabetes,which reduces noncanonical Wnt signal transduction pathway to improve insulin resistance.Further study of biological function of Sfrp5 may offer therapeutic opportunity for obesity and related metabolic disorders.