CAJ | 학술논문

临床上原发性肾病综合征(PNS)继发甲状腺功能异常的病例并不少见.近年来多项研究对于该现象进行了深入的探讨,提出了各种可能的病理生理机制,目前尚无统一定论.早期行甲状腺激素补充及抗氧化应激等治疗,可以帮助患者维持甲状腺功能正常,保护肾小球结构、改善内皮功能障碍、利于原发疾病的缓解等.儿童PNS患者外源摄入甲状腺激素联合依那普利还可促进其自身机体发育、骨骼生长及智力成熟.动态观察患者血清甲状腺激素水平可作为观察病情、判断疗效以及预后的敏感指标.
림상상원발성신병종합정(PNS)계발갑상선공능이상적병례병불소견.근년래다항연구대우해현상진행료심입적탐토,제출료각충가능적병리생리궤제,목전상무통일정론.조기행갑상선격소보충급항양화응격등치료,가이방조환자유지갑상선공능정상,보호신소구결구、개선내피공능장애、리우원발질병적완해등.인동PNS환자외원섭입갑상선격소연합의나보리환가촉진기자신궤체발육、골격생장급지력성숙.동태관찰환자혈청갑상선격소수평가작위관찰병정、판단료효이급예후적민감지표.
It's not uncommon that thyroid dysfunction is secondary to primary nephrotic syndrome.Recently a number of studies have explored this phenomenon and several possible pathophysiological mechanisms have been put forward.However,at present there is no unified conclusion.If thyroid hormone supplement and anti-oxidative stress treatment are given at early stages,patients may benefit a lot such as maintaining normal thyroid function,protecting glomerular structure,improving endothelial dysfunction and easing the primary diseases,etc.Intaking exogenous thyroid hormone as well as enalaprilat also can help children with primary nephrotic syndrome to promote their own body development,bone growth and intellectual maturity.Dynamic monitor of serum thyroid hormone level can served as a sensitive index for illness evaluation,response judgment and prognosis.