国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
1期
20-22
,共3页
糖尿病肾病%二甲双胍%AMPK%氧化应激%炎症
糖尿病腎病%二甲雙胍%AMPK%氧化應激%炎癥
당뇨병신병%이갑쌍고%AMPK%양화응격%염증
Diabetic nephropathy%Metformin%AMPK%Oxidative stress%Inflammation
近年的一些实验及临床观察表明,二甲双胍对糖尿病肾病有着独立于降糖作用之外的保护作用.相关机制可能包括抑制线粒体氧化呼吸链复合体Ⅰ,激活AMP活化蛋白激酶(AMPK),改善肾脏的氧化应激、炎性反应和高滤过状态,抑制晚期糖基化终末产物(AGEs)的生成,减轻肾脏脂质沉积以及肾小球硬化和间质纤维化等.对于合并肾脏并发症,估算的肾小球滤过率(eGFR)大于30 ml/(min·1.73m2)的糖尿病患者,可应用二甲双胍治疗.
近年的一些實驗及臨床觀察錶明,二甲雙胍對糖尿病腎病有著獨立于降糖作用之外的保護作用.相關機製可能包括抑製線粒體氧化呼吸鏈複閤體Ⅰ,激活AMP活化蛋白激酶(AMPK),改善腎髒的氧化應激、炎性反應和高濾過狀態,抑製晚期糖基化終末產物(AGEs)的生成,減輕腎髒脂質沉積以及腎小毬硬化和間質纖維化等.對于閤併腎髒併髮癥,估算的腎小毬濾過率(eGFR)大于30 ml/(min·1.73m2)的糖尿病患者,可應用二甲雙胍治療.
근년적일사실험급림상관찰표명,이갑쌍고대당뇨병신병유착독립우강당작용지외적보호작용.상관궤제가능포괄억제선립체양화호흡련복합체Ⅰ,격활AMP활화단백격매(AMPK),개선신장적양화응격、염성반응화고려과상태,억제만기당기화종말산물(AGEs)적생성,감경신장지질침적이급신소구경화화간질섬유화등.대우합병신장병발증,고산적신소구려과솔(eGFR)대우30 ml/(min·1.73m2)적당뇨병환자,가응용이갑쌍고치료.
Recently,a number of experimental and clinical observations suggest that metformin has a specific protective effect on diabetic nephropathy(DN) independently of its hypoglycemic effect.The mecha-nisms include activating AMP-activated protein kinase through a inhibition of the mitochondrial respiratory chain complex I,improving oxidative stress,inflammation and hyperfiltration of the kidney,reducing the for-mation of advanced glycation end products,lightening lipid deposition,glomerulosclerosis and renal interstitial fibrosis,etc.The use of metformin would be benefitial in DN patients with an estimated glomerular filtration rate higher than 30 ml/(min · 1.73m2).
