国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
1期
32-35
,共4页
胰岛素%内皮细胞%胰岛素抵抗%高胰岛素血症
胰島素%內皮細胞%胰島素牴抗%高胰島素血癥
이도소%내피세포%이도소저항%고이도소혈증
Insulin%Endothelium%Insulin resistance%Hyperinsulinemia
胰岛素作为一个重要的代谢调节激素,还具有保护血管内皮细胞的作用,其作用机制可能为:调节血管内皮因子,抑制内皮细胞的收缩、增强内皮细胞间的紧密连接,防止动脉粥样硬化,调节内皮细胞的生长及活性氧簇(ROS)的表达.因此,胰岛素抵抗和高胰岛素血症导致的胰岛素信号紊乱将减弱胰岛素对内皮细胞的保护作用.然而,胰岛素是否可以成为糖尿病、肥胖等代谢性疾病慢性血管并发症的治疗药物,有待进一步研究.
胰島素作為一箇重要的代謝調節激素,還具有保護血管內皮細胞的作用,其作用機製可能為:調節血管內皮因子,抑製內皮細胞的收縮、增彊內皮細胞間的緊密連接,防止動脈粥樣硬化,調節內皮細胞的生長及活性氧簇(ROS)的錶達.因此,胰島素牴抗和高胰島素血癥導緻的胰島素信號紊亂將減弱胰島素對內皮細胞的保護作用.然而,胰島素是否可以成為糖尿病、肥胖等代謝性疾病慢性血管併髮癥的治療藥物,有待進一步研究.
이도소작위일개중요적대사조절격소,환구유보호혈관내피세포적작용,기작용궤제가능위:조절혈관내피인자,억제내피세포적수축、증강내피세포간적긴밀련접,방지동맥죽양경화,조절내피세포적생장급활성양족(ROS)적표체.인차,이도소저항화고이도소혈증도치적이도소신호문란장감약이도소대내피세포적보호작용.연이,이도소시부가이성위당뇨병、비반등대사성질병만성혈관병발증적치료약물,유대진일보연구.
Insulin,as an important hormone of metabolic regulation,can exert beneficial effects on endothelial protection.Mechanisms of endothelial protection include regulating vascular endothelial media-tors,inactivating the endothelial contraction and enhancing cell-cell adhesions,inhibiting atherosclerosis,reg-ulating the growth of endothelial cells,and the expression of reactive oxygen species (ROS).Disturbance of insulin signaling induced by insulin resistance and hyperinsulinemia will impair its effects on endothelial protection.However,whether insulin can be used as a therapy for chronic vascular complications in metabolic diseases such as diabetes,obesity needs further study.
