CAJ | 학술논문

骨骼肌是葡萄糖摄取和利用的重要组织,也是胰岛素发挥作用的靶组织.骨骼肌病变可加重胰岛素抵抗(IR),进一步影响机体的糖代谢.糖尿病性骨骼肌病变常因其临床表现不典型而被忽视,其发病机制复杂,与血管性因素、神经性因素、代谢性因素、氧化应激、细胞凋亡、慢性炎性反应等均有关.因此,明确其临床特点及发病机制是近年来研究糖尿病性骨骼肌病变的重点.
골격기시포도당섭취화이용적중요조직,야시이도소발휘작용적파조직.골격기병변가가중이도소저항(IR),진일보영향궤체적당대사.당뇨병성골격기병변상인기림상표현불전형이피홀시,기발병궤제복잡,여혈관성인소、신경성인소、대사성인소、양화응격、세포조망、만성염성반응등균유관.인차,명학기림상특점급발병궤제시근년래연구당뇨병성골격기병변적중점.
Skeletal muscle is the most important organization of glucose uptake,utilization,and is also the target tissue of insulin.Skeletal muscle lesion aggravates insulin resistance(IR) which can further in-fluence the glucose metabolism.But diabetic skeletal muscle lesion is usually ignored because of its atypical clinical manifestation.And the pathogenesis is complex which involved in vascular factors,neurological factors and metabolic factors,oxidative stress,apoptosis,chronic inflammatory reaction,etc.Therefore,the clinical characteristics and pathogenesis would be the focus of the research of diabetic skeletal muscle lesion in recent years.