CAJ | 학술논문

胰岛素自身免疫综合征(IAS)是指从未使用过胰岛素的患者发生的严重自发性低血糖,由遗传因素和环境因素共同作用,大部分患者携带DRB1* 0406基因,多合并Graves病等自身免疫性疾病,以服用甲巯咪唑等药物为诱因,以血浆高胰岛素水平、高C肽水平、高滴度的胰岛素自身抗体(IAA)为主要特征.IAS具有自限性,停用诱发药物,辅以低碳水化合物、高蛋白、高纤维饮食,必要时给予小剂量糖皮质激素及免疫抑制剂,多数可缓解.
이도소자신면역종합정(IAS)시지종미사용과이도소적환자발생적엄중자발성저혈당,유유전인소화배경인소공동작용,대부분환자휴대DRB1* 0406기인,다합병Graves병등자신면역성질병,이복용갑구미서등약물위유인,이혈장고이도소수평、고C태수평、고적도적이도소자신항체(IAA)위주요특정.IAS구유자한성,정용유발약물,보이저탄수화합물、고단백、고섬유음식,필요시급여소제량당피질격소급면역억제제,다수가완해.
Insulin autoimmune syndrome (IAS),which shows severe spontaneous hypoglycemia without a history of exogenous insulin administration,is contributed by both genetic factors and environmental factors.Most patients carry the gene DRB1 * 0406,and often accompany with other immune disorders,such as Graves' disease.IAS is characterized by high total serum insulin,high C-peptide levels,and a high titer of in-sulin auto-antibodies (IAA).Moreover,administration of methimazole is considered to be an incentive for it.Besides,IAS is self-limiting,and when stop using the triggered drugs,it can be eased by a low carbonhydrate,high protein,and high fiber diet.A small dose of glueocorticoid can also be applyed when necessary.