国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
2期
89-91
,共3页
脂联素%基因多态性%噻唑烷二酮类药物%2型糖尿病
脂聯素%基因多態性%噻唑烷二酮類藥物%2型糖尿病
지련소%기인다태성%새서완이동류약물%2형당뇨병
Adiponectin%Gene polymorphism%Thiazolidinediones%Type 2 diabetes mellitus
临床研究表明,2型糖尿病患者噻唑烷二酮类药物疗效具有差异性,其差异性的原因可能与过氧化物酶体增殖物活化受体γ(PPARγ)、PPARγ协同刺激因子、脂联素、解耦联蛋白2、β3肾上腺素能受体基因、视黄醇结合蛋白4、细胞色素酶、脂素基因1等基因多态性相关,但是目前尚无一致性结论.目前国内、外关于PPARγ、PPARγ共激活因子、脂联素基因多态性与2型糖尿病患者噻唑烷二酮类药物疗效差异性的研究较多.
臨床研究錶明,2型糖尿病患者噻唑烷二酮類藥物療效具有差異性,其差異性的原因可能與過氧化物酶體增殖物活化受體γ(PPARγ)、PPARγ協同刺激因子、脂聯素、解耦聯蛋白2、β3腎上腺素能受體基因、視黃醇結閤蛋白4、細胞色素酶、脂素基因1等基因多態性相關,但是目前尚無一緻性結論.目前國內、外關于PPARγ、PPARγ共激活因子、脂聯素基因多態性與2型糖尿病患者噻唑烷二酮類藥物療效差異性的研究較多.
림상연구표명,2형당뇨병환자새서완이동류약물료효구유차이성,기차이성적원인가능여과양화물매체증식물활화수체γ(PPARγ)、PPARγ협동자격인자、지련소、해우련단백2、β3신상선소능수체기인、시황순결합단백4、세포색소매、지소기인1등기인다태성상관,단시목전상무일치성결론.목전국내、외관우PPARγ、PPARγ공격활인자、지련소기인다태성여2형당뇨병환자새서완이동류약물료효차이성적연구교다.
Clinical studies showed that in patients with type 2 diabetes mellitus curative effect of thiazolidinediones (TZDs) was different,their differences may be due to the polymorphisms of peroxisome proliferator-activated receptor γ(PPARγ),coactivator-1 α (PGC-1 oα),adiponectin,uncoupling protein 2,β3 adrenergic receptor gene,retinol binding protein 4,cytochrome enzyme and lipid gene 1 and so on.But there is no consistent conclusion up to now.There are more researches on the association of the polymorphisms of PPARγ,PGC-1 α,adiponectin with the curative effect of TZDs in type 2 diabetic patients.
