CAJ | 학술논문

最近的研究发现,与传统的白色和棕色脂肪细胞不同,脂肪组织中还存在另外一种新型的脂肪细胞,它们散在分布于白色脂肪组织中,受寒冷刺激或β3肾上腺素能受体激动剂激活后,表现出棕色脂肪细胞的特点,棕色脂肪细胞特异的解耦联蛋白1(UCP1)等基因的表达显著增高,产热和能量消耗能力增强.这一过程被称为“白色脂肪细胞棕色化”,这些细胞被命名为brite(brown to white)细胞或者beige(the intermediate color between white and brown)细胞.由于beige细胞在机体内分布广泛,并具有显著的消耗能量的功能,因此可能成为未来减肥药物开发的靶点.
최근적연구발현,여전통적백색화종색지방세포불동,지방조직중환존재령외일충신형적지방세포,타문산재분포우백색지방조직중,수한랭자격혹β3신상선소능수체격동제격활후,표현출종색지방세포적특점,종색지방세포특이적해우련단백1(UCP1)등기인적표체현저증고,산열화능량소모능력증강.저일과정피칭위“백색지방세포종색화”,저사세포피명명위brite(brown to white)세포혹자beige(the intermediate color between white and brown)세포.유우beige세포재궤체내분포엄범,병구유현저적소모능량적공능,인차가능성위미래감비약물개발적파점.
Recent studies demonstrated that there was a new kind of adipocytes,which were different from traditional white and brown adipocytes.These adipocytes are scattered in the white adipose tissue and could highly express the brown adipocytes specific genes uncoupling protein 1 (UCP1),which promote heat production and energy consumption,when stimulated by the cold or β3 adrenergic receptor agonist.This process is called browning of white adipocytes,and these cells are called brite (brown to white) cells or beige (the intermediate color between white and brown) cells.In light of their potential function in energy consumption and their wide distribution in the body,the beige cells may become new therapeutic targets for antiobesity in the future.