CAJ | 학술논문

目的确定符合天津市Graves病患者促甲状腺激素受体抗体(TRAb)的诊断灰区.方法通过电化学发光法检测Graves病组(n=157)、甲状腺炎组(n =250)以及正常对照组(n =235)的TRAb血清水平,绘制受试者工作特征(ROC)曲线,计算Graves病最佳诊断切值并确定诊断灰区.结果区分Graves病患者和健康人的TRAb最佳诊断切值为1.725 IU/L,此时ROC曲线下面积为0.996,敏感度为97.5％,特异度为99.6％.区分Graves病患者和甲状腺炎患者的诊断灰区为1.670 ～2.535 IU/L.结论确定Graves病患者TRAb诊断灰区有助于提高诊断特异性和敏感性.
목적 학정부합천진시Graves병환자촉갑상선격소수체항체(TRAb)적진단회구.방법 통과전화학발광법검측Graves병조(n=157)、갑상선염조(n =250)이급정상대조조(n =235)적TRAb혈청수평,회제수시자공작특정(ROC)곡선,계산Graves병최가진단절치병학정진단회구.결과 구분Graves병환자화건강인적TRAb최가진단절치위1.725 IU/L,차시ROC곡선하면적위0.996,민감도위97.5％,특이도위99.6％.구분Graves병환자화갑상선염환자적진단회구위1.670 ～2.535 IU/L.결론 학정Graves병환자TRAb진단회구유조우제고진단특이성화민감성.
Objective To evaluate the diagnostic gray zone of thyrotropin receptor antibody(TRAb) in patients with Graves' disease in Tianjin.Methods Chemiluminescence method was applied to detect the serum levels of TRAb in Graves' disease group (n =157),thyroiditis group (n =250),and normal control group (n =235).The optimal diagnostic cutoff value was calculated and diagnostic gray zone was determined by receiver operating characteristic (ROC) curve.Results ROC analysis resulted in a specificity of 99.6％ with a sensitivity of 97.5％ at cutoff value of 1.725 IU/L with area under the ROC curve is 0.996 from comparison of Graves' disease and healthy volunteers.The diagnostic gray zone of distinction between Graves' disease and thyroiditis was 1.670-2.535 IU/L.Conclusion To evaluate the diagnostic gray zone of TRAb in patients with Graves' disease is very helpful for improving the specificity and the sensitivity of the diagnosis.