CAJ | 학술논문

作为一种神经保护措施,亚低温在临床实践中的应用与研究已非常广泛.许多疾病,如心脏停搏后脑损伤、新生儿缺血缺氧性脑病等,应用亚低温治疗已取得了肯定的疗效.虽然亚低温在治疗缺血性卒中方面已有大量动物实验和临床研究,而且动物实验已证实其具有确切的神经保护作用,但在临床研究中亚低温治疗缺血性卒中的神经保护作用尚未得出一致的结论,其临床疗效似乎并无预期的乐观.因此,有必要对亚低温治疗缺血性卒中由动物实验向临床转化中存在的问题进行分析,为亚低温治疗缺血性卒中的临床应用提供思路.
작위일충신경보호조시,아저온재림상실천중적응용여연구이비상엄범.허다질병,여심장정박후뇌손상、신생인결혈결양성뇌병등,응용아저온치료이취득료긍정적료효.수연아저온재치료결혈성졸중방면이유대량동물실험화림상연구,이차동물실험이증실기구유학절적신경보호작용,단재림상연구중아저온치료결혈성졸중적신경보호작용상미득출일치적결론,기림상료효사호병무예기적악관.인차,유필요대아저온치료결혈성졸중유동물실험향림상전화중존재적문제진행분석,위아저온치료결혈성졸중적림상응용제공사로.
As a neuroprotective measure,the application and research of mild hypothermia in clinical practice have been very extensive.Using mild hypothermia has achieved a positive efficacy in many diseases,such as brain damage after cardiac arrest and neonatal hypoxic-ischemic encephalopathy,etc.Although mild hypothermia has a large number of animal experiments and clinical studies in the treatment of ischemic stroke,and animal experiments have confirmed that it has the exact neuroprotective effect,the neuroprotective effect of mild hypothermia in the treatment of ischemic stroke has not yet come to a unified conclusion in the clinical studies.Its clinical efficacy does not seem to be as optimistic as expected.Therefore,it is necessary to analyze the transforming problems of mild hypothermia for treatment of ischemic stroke from animal experiments to clinical practice,and to provide ideas for the clinical application of mild hypothermia for treatment of ischemic stroke.