CAJ | 학술논문

目的探讨ATP结合盒转运体A1(ATP-binding cassette transporter A1,ABCA1)基因R219K多态性与中国人缺血性卒中的相关性.方法采用全面的文献检索收集2013年5月以前发表的中国人ABCA1基因R219K多态性与缺血性卒中相关性的病例对照研究.采用Stata 11.0软件包进行汇总分析.采用优势比(odds ratio,OR)及其95％可信区间(confidence interval,CI)评价基因多态性与缺血性卒中的关联强度.结果共10项研究符合条件纳入分析,包括病例组1 619例,对照组1 907例,入选文献无明显偏倚.汇总分析显示,RK+KK基因型携带者缺血性卒中风险较RR基因型携带者显著性降低8％(OR0.92,95％ CI 0.88～0.96;P =0.000)；KK基因型携带者的缺血性卒中风险较RR基因型携带者显著性降低36％(OR 0.64,95％ CI 0.44～0.94;P=0.02)；RK基因型携带者的缺血性卒中风险较RR基因型携带者显著性降低19％(OR0.81,95％ CI 0.69～0.95;P=0.009)；K等位基因携带者的缺血性卒中风险较R等位基因携带者显著性降低17％(OR 0.83,95％ CI 0.69～0.99;P=0.036).结论 ABCA1基因R219K多态性与中国人缺血性卒中易感性相关,K等位基因可能是中国人缺血性卒中的遗传保护性因素.
목적 탐토ATP결합합전운체A1(ATP-binding cassette transporter A1,ABCA1)기인R219K다태성여중국인결혈성졸중적상관성.방법 채용전면적문헌검색수집2013년5월이전발표적중국인ABCA1기인R219K다태성여결혈성졸중상관성적병례대조연구.채용Stata 11.0연건포진행회총분석.채용우세비(odds ratio,OR)급기95％가신구간(confidence interval,CI)평개기인다태성여결혈성졸중적관련강도.결과 공10항연구부합조건납입분석,포괄병례조1 619례,대조조1 907례,입선문헌무명현편의.회총분석현시,RK+KK기인형휴대자결혈성졸중풍험교RR기인형휴대자현저성강저8％(OR0.92,95％ CI 0.88～0.96;P =0.000)；KK기인형휴대자적결혈성졸중풍험교RR기인형휴대자현저성강저36％(OR 0.64,95％ CI 0.44～0.94;P=0.02)；RK기인형휴대자적결혈성졸중풍험교RR기인형휴대자현저성강저19％(OR0.81,95％ CI 0.69～0.95;P=0.009)；K등위기인휴대자적결혈성졸중풍험교R등위기인휴대자현저성강저17％(OR 0.83,95％ CI 0.69～0.99;P=0.036).결론 ABCA1기인R219K다태성여중국인결혈성졸중역감성상관,K등위기인가능시중국인결혈성졸중적유전보호성인소.
Objective To investigate the correlation between ATP-binding cassette transporter A1 (ABCA1) R219K polymorphism and ischemic stroke in Chinese populations.Methods The case control studies of the correlation between Chinese ABCA1 R219K polymorphism and ischemic stroke published before May 2013 were collected using comprehensive literature search.The Stata 11.0 software was used to conduct metaanalysis.Odds ratio (OR) and its 95％ confidence interval (CI) was used to evaluate the strength of association between the gene polymorphism and ischemic stroke.Results A total of 10 studies met the criteria and were included in the analysis,including 1 619 patients in the patient group and 1907 in the control group.The selected literature had no obvious bias.Meta-analysis showed that the risk of ischemic stroke in patients carrying RK + KK genotype significantly decreased 8％ (OR 0.92,95％ CI 0.88-0.96; P =0.000)compared to those carrying RR genotype.The risk of ischemic stroke in patients carrying KK genotype significantly decreased 36％ compared to those carrying RR genotype (OR 0.64,95％ CI 0.44-0.94; P =0.02).The risk of ischemic stroke in patients carrying RK genotype significantly decreased 19％ compared to those carrying RR genotype (OR 0.81,95％ CI 0.69-0.95; P =0.009).The risk of ischemic stroke in patients carrying K allele significantly decreased 17％ compared to those carrying R allele (0R 0.83,95％ CI 0.69-0.99; P =0.036).Conclusions ABCA1 R219K polymorphism is associated with the susceptibility of ischemic stroke in Chinese.K allele may be a genetic protective factor for ischemic stroke in Chinese populations.