CAJ | 학술논문

脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)是中枢神经系统中最普遍的神经营养因子之一.在神经系统的发育和成熟过程中,BDNF在维持神经元功能、促进神经元损伤后再生修复以及防止神经元变性等方面均发挥着重要作用.目前,很多学者正致力于BDNF治疗脑缺血的研究,并已取得了一些进展.文章对BDNF的分子生物学特征、生物学功能、在脑缺血中的作用和机制以及作为脑缺血干预靶点的可能性进行了综述.
뇌원성신경영양인자(brain-derived neurotrophic factor,BDNF)시중추신경계통중최보편적신경영양인자지일.재신경계통적발육화성숙과정중,BDNF재유지신경원공능、촉진신경원손상후재생수복이급방지신경원변성등방면균발휘착중요작용.목전,흔다학자정치력우BDNF치료뇌결혈적연구,병이취득료일사진전.문장대BDNF적분자생물학특정、생물학공능、재뇌결혈중적작용화궤제이급작위뇌결혈간예파점적가능성진행료종술.
Brain-derived neurotrophic factor (BDNF) is one of the most prevalent growth factors in the central nervous system (CNS).In the development and maturation processes of the nervous system,BDNF plays an important role in maintaining neuronal function,promoting neuronal regeneration after injury,and preventing neuronal degeneration,etc.At present,many researchers are being dedicated to the research of BDNF for treatment of brain ischemia and have achieved some progress.This article reviews the molecular biological characteristics and biological function of BDNF,roles and mechanisms in cerebral ischemia,and the possibility as an intervention target of cerebral ischemia.